blocking of D2 receptors in the pituitaryWorks by blocking D2 receptors●Neuroleptic-induced deficit syndrome-linked to blockade of D2 receptors in themesolimbic and mesocortical pathways●Dry mouth, blurred vision, urinaryretention, consitpation, and paralytic ileus-linked to the blockade of mus...
NR 546 Week 3 Antipsychotics Drug Table
Drug name Indication Half-life Notable side effects (associate to pathway or NT)
(T1/2),
Target symptoms: state if positive or negative
metabolism
effect Potency (if noted. receptor occupancy if (CYP 450
enzyme)
noted ) Neurotransmitter(s) affected
Typical antipsychotics (conventional)
Haloperidol Dopamine Receptor Antagonist Single dose: ● Akathisia, dystonia, and drug-induced
12-38 hours parkinsonism- linked to blockade of
D2 receptors in the striatum
Chronic use:
Targets the symptoms of psychosis such as
21 days ● Tardive dyskinesia- linked to chronic
hallucinations and delusions. It can also be used to treat
blockade of D2 receptors in the
the tics and vocalizations of Tourette’s, as a second-line
striatum
treatment for hyperactivity and severe behavioral
Substrate
problems in children. ● Galactorrhea/amenorrhea- linked to
CYP450 2D6
blocking of D2 receptors in the
pituitary
Works by blocking D2 receptors to reduce the positive
● Neuroleptic-induced deficit syndrome-
symptoms of psychosis as well as possibly decreasing
linked to blockade of D2 receptors in
combative, explosive, and hyperactive behaviors. Its use
the mesolimbic and mesocortical
in Tourette’s is related to blocking D2 receptors in the
pathways
nigrostriatal pathway.
● Dizziness, hypotension, and syncope-
linked to inadvertent blockade of alpha 1
adrenergic receptors
Thioridazine Dopamine-Serotonin Receptor Antagonist 24 hours ● Akathisia, dystonia, and drug-induced
parkinsonism- linked to blockade of
D2 receptors in the striatum
Targets positive symptoms of psychosis such as CYP450 2D6
● Tardive dyskinesia- linked to chronic
hallucinations, delusions, aggression, and agitation.
blockade of D2 receptors in the
Commonly used for schizophrenic patients who fail
striatum
to respond to other antipsychotic medications.
● Galactorrhea/amenorrhea- linked to
, blocking of D2 receptors in the pituitary
Works by blocking D2 receptors ● Neuroleptic-induced deficit syndrome-
linked to blockade of D2 receptors in
the mesolimbic and mesocortical
pathways
● Dry mouth, blurred vision, urinary
retention, consitpation, and paralytic
ileus- linked to the blockade of muscarinic
cholinergic receptors
● Sedation and weight-gain- linked
to antihistamine actions
● Dizziness, hypotension, and syncope-
linked to inadvertent blockade of alpha 1
adrenergic receptors
● Dose-dependent QTc prolongation-
possibly linked to actions at ion channels
Thiothixene Dopamine 2 Antagonist Initial: 3.4 ● Akathisia, dystonia, and drug-induced
hours parkinsonism- linked to blockade of
D2 receptors in the striatum
Terminal: 34
Targets the positive symptoms of psychosis in
hours ● Tardive dyskinesia- linked to chronic
schizophrenia, can also be used for other
blockade of D2 receptors in the
psychotic disorders and bipolar disorder
striatum
● Galactorrhea/amenorrhea- linked to
CYP450
blocking of D2 receptors in the
unknown
Works by blocking D2 receptors to reduce positive pituitary
symptoms, also has some effect on serotoneric receptors
● Neuroleptic-induced deficit syndrome-
linked to blockade of D2 receptors in
the mesolimbic and mesocortical
pathways
● Dry mouth, blurred vision, urinary
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