MIDTERM STUDY GUIDE FOR PHARMACOLOGY NURSING 6521

the study of the movement of drugs within the body pharmacokinetics the study of the effects of drugs and their mechanism of action pharmacodynamics describes what the body does to the drug through absorption, distribution, metabolism, and excretion pharmacokinetics describes what the drug does to the body pharmacodynamics What is the impact of Cirrhosis on drug levels and dosing? Because medications with a low extraction ratio (e.g., warfarin, phenytoin, carbamazepine, and lorazepam) rely heavily on the metabolic capacity of the liver for intrinsic clearance through CYP 450 enzymes, these medications will be impacted more significantly.Nearly 30% of patients with cirrhosis suffer adverse drug reactions or hepatoxicity if these risk factors are not considered or monitored closely. So Close monitoring of liver functions and doses may need to be reduced due to risk of hepatoxicity.