CPPS 304 Post Mid-Final Exam Questions with Correct Answers

What are two ways to overcome an infection with drug therapy? (List format) - 1. Bactericidal 2. Bacteriostatic What is chemotherapy? - Treatment of disease by chemicals (drugs) that have a specific toxic effect upon disease producing microorganisms, or that selectively destroy cancerous tissue What are the key targets of antibiotics? - Cell wall, ribosomes, DNA/RNA What are the most important drugs by class? - Beta-lactams What are bacteria cell walls made of? - peptidoglycan What is the first step in construction of a bacterial cell wall? - construction of peptidoglycan What is the second step in construction of a bacterial cell wall? - Transport of PG to outer cell membrane What is the third step in construction of a bacterial cell wall? - Linking of PG end to end to form a row What is the fourth step in construction of a bacterial cell wall? - Joining of PG rows to form a stable row What is - What is the most common form of Penicillin? - Amoxicillin What is the most effective group of antibiotics? - cell wall synthesis inhibitors Why are cell wall synthesis inhibitors so successful? - selective toxicity Do we need more antibiotics currently for Gram - or Gram +? - Gram - What PK property would a drug need in order to cross into the CNS? - Lipophilicity What do Fungi have in their cell membrane instead of cholesterol? - Ergosterol What do azole antifungals inhibit? - CYP450 enzymes What is Clotrimazole? - An azole antifungal What is the brand name of Clotrimazole? - Canesten