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MMSC 409 IMMUNOHEME EXAM I WITH COMPLETE SOLUTIONS 100% 2023/2024
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MMSC 409 IMMUNOHEME EXAM I WITH COMPLETE SOLUTIONS 100% 2023/2024
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MMSC 409 IMMUNOHEME EXAM I WITH COMPLETE SOLUTIONS 100% 2023/2024whole blood - correct answer red cells, white cells, platelets and plasma (coagulation factors which all require Ca, additives target Ca to halt the cascade)
in order to have viable, permeable, flexible, floating, bioconcave, oxygenated blood cells you need - correct answer ATP to maintain spectrin
ATP - correct answer cation pumps push sodium out of the cell and potassium into the red blood cell
rigid cells - correct answer sodium and other electrolytes like calcium can accumulate in the red cell
anemia - correct answer rigid red blood cell is removed from circulation in the spleen
more on maintaining viable RBCs - correct answer -generate around 90% ATP through glycolysis, anaerobic process of converting glucose to pyruvate
-decreased ATP leads to reduced phosphorylation of spectrin
-spleen removal of the cells due to decreased membrane deformability
Hemoglobin molecule - correct answer -2 beta and 2 alpha chains, heme group
CPD, CP2D and ACD-A all have an X day expiration - correct answer 21 day
added adenine in CPD has an X day expiration - correct answer 35 day
anticoagulant (sodium citrate) - correct answer prevents clotting monobasic sodium phosphate (shift R/L) - correct answer maintains pH, 21 day expiration (CPD, CP2D, ACD-A)
dextrose (deformability and permeability) - correct answer -substrate for ATP production
-ADD adenine (found in ATP) to extend expiration by 2 weeks (35d)
to extend the expiration to 42 days add each to CDPA1 centrifuged whole blood with plasma removed - correct answer -AS1: adsol
-AS3: nutricel
-AS5: optisol
-AS7: solx
-1/5/7 added mannitol, 3 added citrate/phosphate
-all reduce storage hemolysis due to K+ leaking from cells
alloantibody - correct answer antibody produced after exposure to a nonself antigen
do lymphocytes recognize only one specific antibody - correct answer yes
how is the classical complement pathway activated - correct answer antigen-antibody complex
red cell products - correct answer helps bleeding and anemia
platelets - correct answer helps platelet-related disorders and clotting problems
fresh frozen plasma cryoprecipitate - correct answer helps coagulation disorders and clotting problems
donor collection/manufacturing center - correct answer -collection and processing, retype segment from
red cell units, storage
-test donor unit
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