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UNE MEDICAL BIOCHEM FINAL EXAM QUESTIONS AND ANSWERS.
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UNE MEDICAL BIOCHEM FINAL EXAMQUESTIONS AND ANSWERS
The cellular uptake of LDL increase intracellular cholesterol levels. This has which of the
following impacts on de novo cholesterol synthesis? - answer Increases degradation of HMG-
CoA reductase
Dietary cholesterol is primarily transported in the body by which of the following lipoproteins? -
answer Chylomicrons.
Cholesterol and TG from diet are transported from intestine to liver via chylomicrons.
The LDL receptor is also highly regulated in the cell. Which of the following proteins targets the
LDL receptor for degradation? - answer Proprotein converts subtillisin/kexin type 9 (PSK9)
Bile salts are synthesized from cholesterol and are used for the emulsification of dietary lipids.
What is the primary fate of bile salts during digestion? - answer They are absorbed in the ileum.
Secondary bile salts are excreted in the feces.
A deficiency in the LDL receptor will result in an initial decrease in which of the following? -
answer Intracellular cholesterol
A 45-year-old man has a mild heart attack and a history of vascular disease. He is placed on a
Mediterranean diet and statin drug therapy. Which of the following will be the most likely result
of this drug therapy? - answer Low blood LDLs
Statins: directly reduce de novo cholesterol synthesis and increase LDL receptor expression--
>increase LDL uptake and reduce circulating levels of LDLs
, Secondary bile salts lack a hydroxyl (OH) group when compared to primary bile salts. What is
the consequence of the loss of this group? - answer Secondary bile salts are less soluble.
Less likely to be absorbed.
Which of the following is NOT required for the transport of newly synthesized fatty acids to the
adipose? - answer Carnitine to shuttle the fatty acids out of the mitochondria.
Carnitine shuttle is required for the process of beta-oxidation to transport fatty acyl chains into
the mito.
What is the primary component of a VLDL particle? - answer Triagcylglycerols
From de novo synthesis in the liver.
A 5-year-old presents to her primary care physician. Her mother is concerned due to persistent
diarrhea which is worse when eating fatty foods. The child also has some clinical signs of a
deficiency in vitamins A, D, E, and K (fat soluble vitamins). Based on this information, the child
likely has a deficiency in the ability to synthesize which of the following lipoproteins? - answer
Chylomicrons
Chylomicrons transport dietary fats and fat soluble vitamins.
VLDL particles have which of the following combinations of apoproteins in their mature form? -
answer ApoB100, ApoCII, ApoE
Which of the following is the major source of extracellular cholesterol for human tissues? -
answer LDLs
Primary role of LDL: transport cholesterol to peripheral tissues
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