NURS 615 Exam II 2023 LATEST
QUESTIONS WITH COMPLETE
SOLUTIONS RATED (A+)
What blood values should be monitored with carbamazepine? - CORRECT ANS
Plasma carbamazepine levels should be monitored on a regular basis. The
therapeutic range is 4 to 12 mcg/L. Higher levels can lead to toxic symptoms
consisting of initial adverse effects and also hypertension, tachycardia, ECG
changes, stupor, agitation, nystagmus, urinary retention, respiratory depression,
seizures, and coma. Children and elderly patient may develop toxicity levels below
12.
CBC every 3 to 4 months
Affects RBC, WBC, Platelets
Agranulocytosis, Anemia
What is the pharmacodynamics of carbamazepine? - CORRECT ANS
Carbamazepine is metabolized in the liver and has the unique ability to induce its
own metabolism (autoinduction). Due to autoinduction, initial concentrations within
therapeutic range may later fall despite good compliance. It also induces the
metabolism of many CYP450 enzymes and other substances. Slowly but well
absorbed half life of about 30 hours, shortens to 15 hours when given repeatedly
The exact mechanism of action of carbamazepine is not known, but they are
thought to affect the sodium channels, slowing influx of sodium in the cortical
neurons and slowing the spread of abnormal activity. Carbamazepine exerts its
effect by depressing transmission in the nucleus ventralis anterior of the thalamus.
This area is associated with the spread of seizure discharge.
•Absorption and Distribution
Carbamazepine is absorbed through the stomach, the suspension being absorbed
more quickly than the tablet form. Absorption from the immediate-release tablets is
, NURS 615 Exam II 2023 LATEST
QUESTIONS WITH COMPLETE
SOLUTIONS RATED (A+)
slow and erratic because of its slow water solubility. The drug is highly lipophilic,
resulting in high body tissue binding.
•Metabolism and Excretion
Excretion is through feces and urine.
Average blood levels of carbamazepine occur approximately 6 hours after
administration. Half-life can be as long as 65 hours with initial dosing, but is
typically 12 to 17 hours as administration continues. It is noteworthy that the half-
life after a single dose is much longer than the half-life after long-term use. Steady
state is attained in 2 to 4 days.
What should families be taught regarding the monitoring of seizure activity? -
CORRECT ANS Patients should be monitored for seizure activity, severity, and
duration. Patient should carry medical identification for the seizure disorder. Patient
should report any mood changes or suicidal thoughts. Prevention of seizures. Do
not abruptly end medication increases risk of seizures
What electrolyte imbalance is noted with the administration of topiramate? -
CORRECT ANS Patients taking topiramate may have decreased concentrations
of bicarbonate due to inhibition of carbonic anhydrase and increased renal
bicarbonate loss, leading to hyperchloremic metabolic acidosis. Severe metabolic
acidosis has been reported in infants receiving a topiramate dose of 5mg/kg/day.
Serum bicarbonate levels should be monitored at baseline and periodically
throughout therapy.
What is the pregnancy category for valproate? - CORRECT ANS Pregnancy
Category X.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Courseinstructor. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $14.99. You're not tied to anything after your purchase.
