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Brody's Human Pharmacology, 5th Edition by Lynn Crespo - Test Bank
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Brody's Human Pharmacology, 5th Edition by Lynn Crespo - Test Bank
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,Wecker: Brody’s Human Pharmacology, 5th EditionChapter 01: Pharmacodynamics: Receptors and Concentration-Response Relationships
Test Bank
Multiple Choice
1. The majority of medications available today act on which superfamily of cellular
membrane receptor?
A. Ligand-gated ion channel
B. G-protein-coupled receptor
C. Receptor tyrosine kinase
D. Nuclear hormone receptor
E. Cytokine receptor
ANS: B. The majority of drugs available act on G-protein-coupled receptors.
2. Nalbuphine is an effective pain reliever because of its activity at mu-opioid receptors.
However, if given to a patient who has recently received morphine (which also affects
mu-opioid receptors) for postoperative pain, nalbuphine can worsen his or her pain. Thus
nalbuphine is said to have what kind of activity at mu-opioid receptors?
A. Full agonist
B. Partial agonist
C. Competitive antagonist
D. Non-competitive antagonist
E. Allosteric modifier
ANS: B. Nalbuphine is a partial agonist at opioid receptors.
,Wecker: Brody’s Human Pharmacology, 5th Edition
Chapter 02: Pharmacokinetics: Absorption, Distribution, Metabolism, and Elimination
Test Bank
Multiple Choice
1. Which of the following features of a drug would enhance its uptake in the GI tract?
A. Polar
B. Water soluble
C. Ionized
D. Low molecular weight
E. Low concentration gradient
ANS: D. Of the options given, only a low molecular weight will increase uptake of a
drug by the GI tract.
2. Which organ contains predominantly tight intercellular junctions, thereby restricting
its uptake of drugs?
A. Kidney
B. Liver
C. Brain
D. Heart
E. Lungs
ANS: C. The brain contains tight intercellular junctions, forming the “blood-brain
barrier.”
3. Drugs commonly undergo all of the following types of metabolism in the liver
EXCEPT FOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS: A. Polymerization is not a common process by which drugs are hepatically
metabolized.
4. Which organ contains predominantly tight intercellular junctions, thereby restricting
its uptake of drugs?
A. Kidney
, B. Liver
C. Brain
D. Heart
E. Lungs
ANS: C. The brain contains tight intercellular junctions, forming the “blood-brain
barrier.”
5. Drugs commonly undergo all of the following types of metabolism in the liver
EXCEPT FOR:
A. Polymerization
B. Conjugation
C. Oxidation
D. Reduction
E. Hydrolysis
ANS: A. Polymerization is not a common process by which drugs are hepatically
metabolized.
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