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Sample Final exam answers: Intro to Biopharmaceutical Science
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Sample Final exam answers Intro to Biopharmaceutical Science BPS 2110 (Professor William Ogilvie)
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Complete the following table describing the stages of drug development. (9 points)Use a diagram to describe the way that a non-competitive inhibitor works. (5 Points)
A non-competitive inhibitor binds to a different location on the enzyme than the substrate does.
Inhibitor binding prevents formation of the ES complex. This type of inhibitor alters kcat and
Vmax but does not affect Km
H-Bond donors: 4 H-Bond acceptor: 8 ⇒ No violation of Lipinsky’s rules, likely bioavailable.
, H-Bond donors: 6 H-Bond acceptor: 11 ⇒ 4 violations of Lipinsky’s rule: LogP is above 5,
MW is over 500 and number of hydrogen bond acceptors is more than 10 and acceptors over 5,
therefore the drug is unlikely to be bioavailable.
The following molecule was once considered as a drug candidate by a large
pharmaceutical company. The acid-base behavior of each of the functional groups is
indicated.
a) Write the pKa expression for the first functional group and identify an appropriate pKa value
using the table provided. (3 Points)
b) Write the pKa expression for the second functional group and identify an appropriate pKa
value using the table provided. (3 Points)
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