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CPHON - Complete Guide
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CPHON - Complete GuideExamples of Alkylating Agents ✔️Ans - Carboplatin, Cisplatin,
Carmustine, Lomustine, Cytoxan, Ifosfamide, Melphalan, Temozolomide,
Thiotepa
Examples of Antimetabolites (Cell-cycle Specific) ✔️Ans - MTX, 5-FU,
ARA-C, 6-MP, 6-TG
Examples of Plant Detrivatives (Cell-cycle Specific) ✔️Ans - Etoposide,
irinotecan, vincristine
Examples of Antibiotics for Cancer treatment ✔️Ans - Dactinomycin,
Bleomycin
Examples of Anthracyclines ✔️Ans - Doxorubicin, Daunorubicin
Misc chemotherapy class examples ✔️Ans - Peg, procarbazine,
decarbazine
If Extravasation, apply cold compresses for every chemo except ✔️Ans -
Vincristine and Etoposide. Apply warm compress for these chemos
Common late effect of Alkylating Agents ✔️Ans - Thyroid
Abnormalities. Examples: Cytoxan, Melphalan, Ifos, and Busulfan
Common late effect of anthracyclines ✔️Ans - Cardiac Toxicity.
Examples: Doxo, Dauno, and Mitoxantrone
Common late effect of vinca alkaloids ✔️Ans - Peripheral Neuropathy.
Examples: Vincristine, Vinblastine, Etop
Common late effect of heavy metal agents ✔️Ans - Hearing Deficits.
Examples: Cisplatin and Carboplatin
Common late effect of Hormone Agents ✔️Ans - Cataracts, Glaucoma,
Uveitis: Prednisone and Dexamethasone
,Common Cancers with Late Thyroid Issues ✔️Ans - Hodgekins, Germ
Cell, CNS tumors, NBL treated with radiolabeled Ab, BMT with TBI
Common Cancers with Late GU Issues ✔️Ans - NBL, Wilm's, Fanconis
Common Cancers with Late Reproductive Issues ✔️Ans -
Medulloblastoma, Osteosarcoma, Ewings, and HSCT
Common Cancers with Secondary Malignancy Risk ✔️Ans - AML,
Sarcomas, Thyroid, Colorectal, Skin, and CNS Tumor
Common Cancers with Late CNS issues ✔️Ans - Phil + ALL and T Cell
ALL
Chemotherapy for ALL ✔️Ans - ARA-C, Doxo, Steroids, Mtx, Vcr, Peg,
6mp
Chemotherapy for AML ✔️Ans - ARA-C, Doxo, Steroids, Etop, 6tg
Chemotherapy for NHL (overall) ✔️Ans - ARA-C, Doxo, Prednisone,
MTX, VCR, Cytoxan, Etop, Ifos
Chemotherapy for HL ✔️Ans - Prednisone, MTX, VCR, Cytoxan, Etop,
Bleo, Procarb/dac, Vinblastine
Chemotherapy for Brain Tumors ✔️Ans - VCR, Cytoxan, Etop,
Carbo/cisplatin, Thiotepa, Carmustine/Lomustine, Temozolomide,
Irinotecan
Chemotherapy for NBL ✔️Ans - VCR, Cytoxan, Etop, Carbo/cisplatin,
Thiotepa, Doxo, Melphalan
Chemotherapy for Wilm's Tumor ✔️Ans - VCR, Cytoxan, Etop, Doxo,
Dactino, Carbo
Chemotherapy for Rhabdo and Ewings ✔️Ans - VCR, Cytoxan, Etop,
Doxo, Dactino, Ifos
, Chemotherapy for Osteosarcoma ✔️Ans - HDMTX, Doxo, Cisplatin,
Ifos/Etop
Chemotherapy for Retinoblastoma ✔️Ans - Carbo, Etop, VCR (CEV)
Late Effect of ARA-C ✔️Ans - Neurocognitive
Late Effect of MTX ✔️Ans - Neurocognitive, Hepatic, Bone Loss
Late Effect of VCR ✔️Ans - Peripheral Neuropathies
Late Effect of Doxorubicin ✔️Ans - Cardiotoxic, Hepatic, and Secondary
Malignancy
Late Effect of 6-MP ✔️Ans - Hepatic
Late Effect of Steroids ✔️Ans - Osteopenia/porosis/necrosis, Cataracts
Late Effect of Cytoxan ✔️Ans - Bladder/Urinary Tract (Include Cancer),
Alkylating Agent Effects (Reproductive, Thyroid, MDS, and 2nd Malignancy)
Alkylating Agent Effects ✔️Ans - Reproductive, Thyroid, MDS, and 2nd
Malignancy
Late Effect of Ifosfamide ✔️Ans - Renal, Bladder, Urinary Trace (Include
Cancer), reproductive issues
Late Effect of Etoposide ✔️Ans - Peripheral Neuropathies, Secondary
Malignancy
Late Effect of Dactinomycin ✔️Ans - Hepatic
Late Effect of Cisplatin and Carboplatin ✔️Ans - Peripheral Neuropathy,
Renal, Ototoxic, Alkylating Agent Effects
Late Effect of Bleomycin ✔️Ans - Pulmonary Fibrosis, interstitial
Pneum
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