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CPHON Study Guide – Verified Solutions
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CPHON Study Guide – Verified Solutions
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CPHON Study Guide – Verified SolutionsWhat does Hydroxyurea stimulate? ✔️Ans - fetal hgb
What is Rituximab? ✔️Ans - Monoclonal antibody
acts against CD20
used for Burkitts Lymphoma
Where is erythropoietin produced? ✔️Ans - kidneys
epryhropoietin: regulates and controls the production of maturation of
RBCs
What is Septra and Dapsone for? ✔️Ans - to prevent pneumocystis
jiroveci.
What can Septra (Bactrim) cause? ✔️Ans - bone marrow suppression
Imatinib is best treatment for.... ✔️Ans - CML
What can Tacrolimus cause? ✔️Ans - reversible posterior
encephalopathy
Dactinomycin can cause? ✔️Ans - radiation recall
Bleomycin can cause? ✔️Ans - pulmonary fibrosis. Make sure to tell
anesthesia before being put to sleep. You cannot hyper oxygenate bc it will
make it worse.
What chemos have a max dose? ✔️Ans - Bleomycin
Doxorubicin 550mg/m2
What can Asparaginase cause? ✔️Ans - Pancreatitis and High blood
sugar
What can VP16 cause? ✔️Ans - secondary AML
,Alkylating agents are responsible for... ✔️Ans - fertility issues. Think of
transplant chemos and high dose chemos like cisplatin, ifosphamide
What is the first line of treatment for hemolytic anemia? ✔️Ans -
Steroids
What drug is given for iron overload? ✔️Ans - Deferoxamine it is a
chelating agent
Most common childhood cancer? ✔️Ans - ALL
Most common solid tumor cancer? ✔️Ans - Brain tumors
Astrocytoma: most common brain tumor
Medulloblastoma: most common malignant brain tumor
Most common extracranial solid tumor? ✔️Ans - NB
Alkylating Agents.... ✔️Ans - interrupts the cell cycle
cytoxan (cycle)
Ifosfamide
Lomustine
Carmustine
Buslfan
Procarbazine
Temozolimide
Decarbazine
Cisplatin
Carboplatin
Antitumor Antiboitics.... ✔️Ans - interfere with cell metabolism
Dactinomycin
Bleomycin
Daunorubicin
Doxorubicin
Idarubicin
Antimetabolites.... ✔️Ans - Stops the ability at the nucleus
5FU
6MP
, Gemcitabine
Fludarabine
Cytrarbine
Hydroxyurea
Methotrexate
Plant Alkaloids.... ✔️Ans - cause DNA breakdown
VP16
Paclitaxel
Docetaxel
Topotecan
Irinotecan
Vincristine:max single dose 2mg
Vinblastine
Vinorelbine
Miscellaneous... ✔️Ans - mechanisms not understood
Asparaginase
Retinoids
Imatinib (Gleevac)
Ambisome ✔️Ans - antifungal
check K
think about pt on antibiotics for 1 week and still having F/N think fungal
What are Biologic Response Modifiers (BRM)? ✔️Ans - attack targeted
pathways and tumor receptor sites
What scan is gold standard with NB? ✔️Ans - MIBG
What is Flagyl used for? ✔️Ans - Cdiff
Tacrolimus side effects? ✔️Ans - Hypomagnesium
Hearling loss
Dizzy
What does Mag sulfate prevent with Cisplatin? ✔️Ans - leg cramps
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