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OCN Drugs Questions with solutions 2023 $16.99   Add to cart

Exam (elaborations)

OCN Drugs Questions with solutions 2023

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Exam of 13 pages for the course OCN at OCN (OCN Drugs)

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  • December 19, 2023
  • 13
  • 2023/2024
  • Exam (elaborations)
  • Questions & answers
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OCN Drugs

Biotherapy - answer the treatment of disease using substances obtained or derived
from living organisms.

Tyrosine kinase inhibitors: MOA, examples, - answer MOA: TKIs bind to the tyrosine
kinase in EGFR, inactivating it or limiting its activity.

-tinib

Erlotinib
Ponatinib
Imatinib
Dasatinib
Ibrutinib

Kinase inhibitors - answer MOA: Kinase inhibitors target the RAF/RAS/MET pathway

-nib

Sorafenib,
Dabrafenib
Trametinib
Vemurafenib

PI3K inhibitors - answer MOA: The PI3K pathway regulates cell survival and
proliferation. When abnormal activation of this pathway occurs, scientists identified
survival and proliferation of tumor cells in many cancers.

-lisib

Idelalisib

Hedgehog - answer MOA:The Hedgehog Pathway is known to most by its role in
normal embryonic development (e.g., brain and spinal cord development). In adults, the
sonic hedgehog pathway controls cell division of adult stem cells and cell differentiation.

-gib

Sonidegib
Vismodegib

, Targeted therapy side effects - answer -sensitivity
-skin rash
-cardiovascular
-bleeding/clotting
-impaired wound healing

Hormone therapy MOA - answer Block the hormones from acting,
Prevent the body from producing the hormone,
Eliminate the hormone receptors on the cell surface or change their shape

Antiestrogens - answer hormone therapies, tamoxifen, fulvestrant

Aromatase inhibitors - answer hormone therapies, anastrozole, exemestane

Antiandrogens - answer hormone therapies, bicalutamide, flutamide

Luteinizing hormone releasing hormone agonist - answer hormone therapies,
goserelin, leuprolide

G0 phase - answer A nondividing state in which a cell has left the cell cycle.

G1 phase - answer cell starts making more proteins and growing larger

S phase - answer the chromosomes containing the genetic code (DNA) are copied,

G2 phase - answer the cell checks the DNA and gets ready to start splitting into two
cells

M phase - answer mitosis, cell splits into two new cells

Alkylating agents MOA - answer interfere with DNA replication, RNA transcription,
and nucleic acid function. Cell cycle nonspecific

Alkylating Agents types - answer Non-platins and platinoids

Alkylating Agents Side Effects - answer bone marrow damage, can lead to Acute
leukemia, infertility

Non-platins - answer Nitrogen mustards: Mechlorethamine, chlorambucil,
cyclophosphomide, ifosfamide, melphalan

Nitrosoureas: Streptozocin, carmustin, lomustine

Alkyl sulfonates: Busulfan
Triazines: Dacarbazine, temozolomide

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