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OCN Chemotherapy Drug Groups Questions and Answers 2023
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OCN Chemotherapy Drug Groups
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OCN Chemotherapy Drug GroupsVesicant chemotherapy agents include: - answer Dactinomycin, daunorubicin,
doxorubicin, epirubicin, idarubicin, mechlorethamine, mitomycin, mitoxantrone,
paclitaxel, streptozocin, tenoposide, vinblastine, vincristine, vinorelbine.
Alkylating Agents (CELL CYCLE NONSPECIFIC)
Alkylating Agents are most active in the resting phase of the cell. These types of drugs
are CELL-CYCLE NONSPECIFIC. There are several types of alkylating agents used in
chemotherapy treatments: - answer Mustard gas derivatives: Mechlorethamine,
Cyclophosphamide, Chlorambucil, Melphalan, and Ifosfamide.
Ethylenimines: Thiotepa and Hexamethylmelamine.
Alkylsulfonates: Busulfan.
Hydrazines and Triazines: Altretamine, Procarbazine, Dacarbazine and Temozolomide.
Nitrosureas: Carmustine, Lomustine and Streptozocin. Nitrosureas are unique because,
unlike most types of chemo treatments, they can cross the blood-brain barrier. They can
be useful in treating brain tumors.
Metal salts: Carboplatin, Cisplatin, and Oxaliplatin.
Plant Alkaloids (CELL CYCLE SPECIFIC mainly M phase)
Plant alkaloids are chemotherapy treatments derived made from certain types of plants.
The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The
taxanes are made from the bark of the Pacific Yew tree (taxus). The vinca alkaloids and
taxanes are also known as antimicrotubule agents. The podophyllotoxins are derived
from the May apple plant. Camptothecan analogs are derived from the Asian "Happy
Tree" (Camptotheca acuminata). Podophyllotoxins and camptothecan analogs are also
known as topoisomerase inhibitors, which are used in certain types of chemotherapy.
The plant alkaloids are CELL CYCLE SPECIFIC. This means they attack the cells
during various phases of division. - answer Vinca alkaloids: Vincristine, Vinblastine
and Vinorelbine.
Taxanes: Paclitaxel and Docetaxel.
Podophyllotoxins: Etoposide and Tenisopide.
Camptothecan analogs: Irinotecan and Topotecan.
Antitumor Antibiotics (CELL CYCLE NONSPECIFIC)
Antitumor antibiotics are chemo treatments made from natural products produced by
species of the soil fungus Streptomyces. These drugs act during multiple phases of the
cell cycle and are considered CELL CYCLE NONSPECIFIC - answer Anthracyclines:
Doxorubicin, Daunorubicin, Epirubicin, Mitoxantrone, and Idarubicin.
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