Exam (elaborations)
APHON Principles Of Chemo And Biotherapy – Questions With Solutions
- Course
- Institution
APHON Principles Of Chemo And Biotherapy – Questions With Solutions
[Show more]
Seller
Follow
LeCrae
Reviews received
Content preview
APHON Principles Of Chemo And Biotherapy –Questions With Solutions
Biotherapy ✔️Ans - Targeted anticancer agents also known as biological
response modifiers (BRM)
Tyrosine kinase inhibitors (TKIs) are what class ✔️Ans - Biotherapy
Monoclonal antibodies (MoAbs) are what class ✔️Ans - Biotherapy
Define pharmacokinetics ✔️Ans - Study of drug absorption, metabolism, and
excretion
Define pharmacodynamics ✔️Ans - The concentration of the drug in the
body and how it produces a response
Define adjuvant chemotherapy ✔️Ans - The use of chemo after another type
of therapy, such as surgery, to treat residual disease or undetectable
metastasis.
Define neoadjuvant chemotherapy ✔️Ans - When chemo is used
preoperatively to decrease tumor burden in order to make it easier to remove
the tumor surgically.
Define sanctuary sites ✔️Ans - Sites within the body where tumor cells
sequester and are not easily reached by chemo such as the CNS
What normal cells are most often effected by chemotherapy ✔️Ans -
Hematopoietic, mucosal (mouth & GI), hair follicles
Why use chemotherapy ✔️Ans - To prevent cancer cells from dividing,
metastasizing, and ultimately causing the death of the patient
Cure ✔️Ans - To permanently eradicate the cancer
Control ✔️Ans - To extend the length & QOL when cure is not feasible or
realistic
, Palliation ✔️Ans - Minimize pain and suffering during end of life
Resting phase of cell cycle ✔️Ans - Gap 0 - cells not dividing
Postmitotic phase ✔️Ans - Gap 1 - enzymes needed for DNA synthesis are
produced, protein and RNA synthesis takes place (18 Hours)
Synthesis (S) Phase ✔️Ans - Cellular DNA duplicated (20 hours)
Premitotic phase ✔️Ans - Gap 2 - both protein and RNA synthesis occur,
precursors of mitotic spindle are produced. Shortest phase
Mitosis (M) Phase ✔️Ans - Cell division occurs in 4-step phase (prophase,
metaphase, anaphase, telophase) 1 Hour
5 stages of reproduction of cells ✔️Ans - Resting, Postmitotic, synthesis,
premitotic, mitosis
Cell Cycle time ✔️Ans - The amount of time it takes a cell to move from one
mitotic episode to another.
Cell-cycle-specific agents ✔️Ans - Those drugs that work only when cells are
in a specific phase of the cell cycle.
Doubling time ✔️Ans - The time required for a tumor mass to reach a certain
size or double in size.
Growth fraction ✔️Ans - Percentage of cells actively dividing at any given
point in time.
Tumor burden ✔️Ans - Size of the tumor as determined by the number of
cells present.
A higher growth fraction ✔️Ans - Results in a higher cell kill with exposure
to cell cycle specific agents.
The higher the tumor cell burden ✔️Ans - The greater the probability of the
development of drug resistance
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller LeCrae. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
82191 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now