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USMLE step 1 Pharmacology MCQ questions on Central Nervous System Antiseizure, Hypnotic, Antiparkinsonian, Narcotic - Ethyl Alcohol drugs - 2023 - your guide to surpass the exam with model answers$13.49
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USMLE step 1 Pharmacology MCQ questions on Central Nervous System Antiseizure, Hypnotic, Antiparkinsonian, Narcotic - Ethyl Alcohol drugs - 2023 - your guide to surpass the exam with model answers
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Course
Pharmacology
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Pharmacology
USMLE step 1 Pharmacology MCQ questions on Central Nervous System Antiseizure, Hypnotic, Antiparkinsonian, Narcotic - Ethyl Alcohol drugs - 2023 - your guide to surpass the exam with model answers - Analgesics
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c) Triazolam
d) Flumazenil
025. Which of the following hypnotic agents is able to interact with both BZ1 and BZ2 receptor subtypes?
a) Zaleplon
b) Phenobarbital
c) Flurazepam
d) Zolpidem
026. Indicate the competitive antagonist of BZ receptors:
a) Flumazenil
b) Picrotoxin
c) Zolpidem
d) Temazepam
027. Flumazenil blocks the actions of:
a) Phenobarbital
b) Morphine
c) Zolpidem
d) Ethanol
028. Indicate the agent, which interferes with GABA binding:
a) Flurazepam
b) Bicuculline
c) Thiopental
d) Zolpidem
029. Which of the following agents blocks the chloride channel directly?
a) Secobarbital
b) Flumazenil
c) Zaleplon
d) Picrotoxin
030. Which of the following agents is preferred in the treatment of insomnia?
a) Barbiturates
b) Hypnotic benzodiazepines
c) Ethanol
d) Phenothiazide
031. Barbiturates are being replaced by hypnotic benzodiazepines because of:
a) Low therapeutic index
b) Suppression in REM sleep
c) High potential of physical dependence and abuse
d) All of the above
032. Which of the following benzodiazepines is used mainly for hypnosis?
a) Clonozepam
b) Lorazepam
c) Flurazepam
d) Midazolam
033. Indicate the main claim for an ideal hypnotic agent:
a) Rapid onset and sufficient duration of action
b) Minor effects on sleep patterns
c) Minimal “hangover” effects
d) All of the above
034. Which stage of sleep is responsible for the incidence of dreams?
a) REM sleep
b) Slow wave sleep
c) Stage 2NREM sleep
d) All of the above
035. During slow wave sleep (stage 3 and 4 NREM sleep):
a) Dreams occur
b) The secretion of adrenal steroids is at its highest
c) Somnambulism and nightmares occur
d) The secretion of somatotropin is at its lowest
036. All of the hypnotic drugs induce:
a) Increase the duration of REM sleep
b) Decrease the duration of REM sleep
c) Do not alter the duration of REM sleep
, 37
d) Increase the duration of slow wave sleep
037. Which of the following hypnotic drugs causes least suppression of REM sleep?
a) Flumazenil
b) Phenobarbital
c) Flurazepam
d) Secobarbital
038. Although the benzodiazepines continue to be the agents of choice for insomnia, they have:
a) The possibility of psychological and physiological dependence
b) Synergistic depression of CNS with other drugs (especially alcohol)
c) Residual drowsiness and daytime sedation
d) All of the above
039. Hypnotic benzodiazepines can cause:
a) A dose-dependent increase in both REM and slow wave sleep
b) Do not change sleep patterns
c) A dose-dependent decrease in both REM and slow wave sleep
d) A dose-dependent increase in REM sleep and decrease in slow wave sleep
040. Which one of the following hypnotic benzodiazepines is more likely to cause rebound insomnia?
a) Triazolam
b) Flurazepam
c) Temazepam
d) All of the above
041. Which of the following hypnotic benzodiazepines is more likely to cause “hangover” effects such as drowsiness,
dysphoria, and mental or motor depression the following day?
a) Temazepam
b) Triazolam
c) Flurazepam
d) None of the above
042. Indicate the hypnotic drug, which binds selectively to the BZ1 receptor subtype, facilitating GABAergic inhibition:
a) Thiopental
b) Zolpidem
c) Flurazepam
d) Phenobarbital
043. Which of the following statements is correct for zolpidem?
a) Causes minor effects on sleep patterns
b) The risk of development of tolerance and dependence is less than with the use of hypnotic benzodiazepines
c) Has minimal muscle relaxing and anticonvulsant effects
d) All of the above
044. Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects?
a) Flurazepam
b) Triazolam
c) Zaleplon
d) None of the above
045. Zolpidem and zaleplon have effectiveness similar to that of hypnotic benzodiazepines in the management of sleep
disorders.
a) True
b) False
046. Which of the following hypnotic drugs is used intravenously as anesthesia?
a) Thiopental
b) Phenobarbital
c) Flurazepam
d) Zolpidem
047. Indicate the usual cause of death due to overdose of hypnotics:
a) Depression of the medullar respiratory center
b) Hypothermia
c) Cerebral edema
d) Status epilepticus
048. Toxic doses of hypnotics may cause a circulatory collapse as a result of:
a) Blocking alfa adrenergic receptors
b) Increasing vagal tone
c) Action on the medullar vasomotor center
d) All of the above
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