LTP Exam Questions with Correct Answers

LTP Exam Questions with Correct Answers Which pathway is non-associative?(non-hebbian) - Answer-Mossy fiber pathway NMDA activation independent Which pathways are associative?(hebbian) - Answer-perforant, schaffer collateral, recurrent NMDA dependent What is an associative LTP pathway? - Answer-depends on NMDA activation and the Calcium influx for the induction of LTP depends on pre and postsynaptic events What is an a non-associative LTP pathway? - Answer-independent of NMDA activation and Ca2+ influx for induction of LTP What causes the expression of LTP? - Answer-CamKII What causes the induction of LTP? - Answer-NMDA activation and Ca2+ influx What's responsible for the maintenance of LTP? - Answer-PKA, PKC, MAPK, CAMKs What are the pathways? (know anatomy of the rodent hippocampus and the entorhinal cortex) - Answerexperiments, primer review? - Answerdraw picture of mech - AnswerWhy LTP - Answer-1) long-lasting 2) fast induction 3) input-specific 4) associative and non-assoicative LTP 5) in hippocampus and other areas of the brain involved in learning and memory 6) memory should be flexible long term potentiation - Answer-phenomenon whereby a high frequency stimulus (HFS) produces a long-lived enhancement in the postsynaptic cells' response to subsequent single-pulse stimuli in the presynaptic fibers long term depression - Answer-phenomenon whereby persistent weak synaptic stimulation produces a long-lived reduction in the postsynaptic cell's response to subsequent single -pulse stimuli LTD - Answer-associative and depends on NMDA receptor activity