NMTCB PET certification Review Study Guide 2024 with complete solution

NMTCB PET certification Review Study Guide 2024 with complete solution Rb-82 Genertaor Alert Level - Answer ️️ -14L of eleute volume reached, or Sr-82 level 0.002uCi/mCi of Rb-82, or Sr-85 level 0.02uCi/mCi of Rb-82 Actions for Rb82 Generator Alert Level - Answer ️️ -Test after every 750 mL has passed through generator Stop using Rb-82 generator if - Answer ️️ -17L of eleute volume reached, or 42 days post calibration date, or Sr82 levenis 0.01uCi/mCi of Rb82, or Sr85 level reaches 0.1uCi/mCi of Rb82 Cyclotron produced isotopes and half-life - Answer ️️ -C11, 20.3 min; N13 9.97 min; O15 2.03 min; F18, 109.7 min Advantages of negative ion cyclotrons - Answer ️️ -1) less nuclear activation of cyl potion cavity and surroundings, 2) can self-focus beam of particles, 3) can irradiate 2 targets at once Isotopes produces by negative ion cyclotrons - Answer ️️ -C, N, O = metabolites Reaction for chemical labeling of F18-FDG - Answer ️️ -Nucleophilic substitution Chemical reaction of FDG - Answer ️️ -Electron rich group of atoms change place on molecule with a positively charged leaving group Precursor molecule for FDG - Answer ️️ -Mannose triflate Chem formula of FDG - Answer ️️ -2-deoxy-2-[18F]fluoro-D-glucose. (Fludeoxyglucose F-18) Intermediate step in FDG synthesis - Answer ️️ -Alkaline hydrolysis of 4 acetyl groups by replacing with OH Size filter used after purification - Answer ️️ -0.22 um FDA ref for PET pharma production - Answer ️️ -General chapter 823 FDG QA appearance - Answer ️️ -Colorless liquid FDG QA radiochemical identity - Answer ️️ -Thin-layer chromatography Rf value to reference standard FDG QARadionuclide identity - Answer ️️ -Half-life 105 and 115 minutes FDG QA bacterial endotoxins test - Answer ️️ -LAL (Limulus amebocyte lysate) <175 USP endotoxins units per max volume injection; endotoxins< 17.5 EU FDG QC pH - Answer ️️ -Between 4.5 to 7.5 FDG QA Radiochemical purity - Answer ️️ -Thin-layered chromatography radioactive Rf should be not less than 90% of total radioactivity of chromatography plate FDG QC Radionuclideic purity - Answer ️️ -should be >99.5% of radionuclidie specified. tested using multi-channel analyzer with peaks at 0.511 and 1.022 MeV FDG QC chemical purity - Answer ️️ -testing depends upon synthesis method used to create FDG Kryptofix 222 - Answer ️️ -FDG QC chemical purity test - thin-layer paper chromatography spot test. 50 ug/mL and FDG solution must dem