Drugs acting on CNS
Motor area (controls motor movement of opposite side of the body)
Higher centers Sensory area (memorize & transmit sensations to thalamus, motor areas, …etc)
Psychic area (memorize sensations, controls mood, intelligence…etc)
III- Hindbrain:
Cerebral cortex Cerebellum
Pons
Medulla oblongata (See below)
, General mode of action
• It’s a balancing act among excitatory vs inhibitory
neurotransmitters within CNS.
, Therapeutic targets in cns
In other words: sites of CNS drug actions:
• Synthesis.
• Storage.
• Release.
• Receptors.
• Reuptake.
• Degradation.
• Ion channels.
• 2nd messengers.
, Examples
In basal ganglia:
Normal
DA ACh
DA
ACh
Pharmacological intervention:
Administration of Levo -DOPA, the precursor of Dopamine synthesis.
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