This document provides the student with MCQs & TFQs with ANSWERS on drugs acting on CNS, including:
CNS stimulants
CNS depressants:
Sedative & Hypnotics
Anticonvulsants (Antepileptics)
Tranquilizers
Analgesics
Anaesthetics
PHARMACOLOGY, CENTRAL NERVOUS (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
INTRODUCTION TO CNS
TRUE/FALSE Questions
Each of the next questions consists of TWO statements; judge if they are True or False & then choose:
Ⓐ If the FIRST statement ONLY is TRUE
Ⓑ If the SECOND statement ONLY is TRUE
Ⓒ If BOTH statements are TRUE
Ⓓ If BOTH statements are FALSE
# 1st statement 2nd statement Answer
Dopamine is an inhibitory transmitter in basal
Q1 L-dopa is given as an antiparkinsonian C
ganglia
Q2 Glycine is an excitatory transmitter in spinal cord Strychnine enhances its release from spinal neurons D
Q3 ACh is the main transmitter in memory center Benztropine could be given for induction of amnesia C
Q4 Rivastigmine can be given to control Alzheimer’s The mechanism is direct activation of M1 receptor A
5-HT is among transmitters involved in vomiting
Q5 Metoclopramide inhibits 5-HT receptor A
reflex
Q6 Dopamine is involved in vomiting reflex Granisetron inhibits D2 receptor in CTZ A
Q7 Histamine is an excitatory transmitter within CNS Dramamine can block H1 receptor C
Q8 GABA is an excitatory transmitter within CNS Chloralhydrate can block GABA-A receptor D
Q9 Barbiturates are CNS depressants They enhance GABA release at many parts of CNS A
Q10 Diazepam has tranquilizing effect It increases Cl- ion influx into neuronal cells C
Q11 Chloralhydrate has central depressant effect It produces so via a site on GABA-A receptor C
Adenosine is among inhibitory transmitters in
Q12 Xanthines may antagonize adenosine effect C
CNS
Q13 Blocking Na channels produces central excitation Phenytoin opens Na channels to reduce epilepsy D
Q14 ACHE inhibition is the target of physostigmine The drug can be used to control Alzheimer’s C
Q15 Neuronal sensation is mediated via Na channels Procaine can block neuronal Na channels C
Q16 Local anaesthesia is mediated via Na-Ch blocking Amethocaine is an example C
Q17 Phosphodiesterase (PDE) hydrolyses cAMP Caffeine reserves cAMP via inhibiting PDE B
Glutamate is among inhibitory transmitters Lamotrigine is an antiepileptic via inhibiting glutamate
Q18 B
within CNS release
Q19 Prolactin release is mediated by Dopamine Bromocriptine is a Dopamine analogue B
Q20 NOS inhibits synthesis of NO in neurons l-NAME inhibits NOS C
[End of questions; Total points = 20]
CNS Pharmacology Surviving Revision
, BENHA UNIVERSITY, CREDIT HOURS SYSTEM
PHARMACOLOGY, CENTRAL NERVOUS (PHA311)
FOR STUDENTS ENROLLED IN PHARMACOLOGY PROGRAMS
CNS STIMULANTS
MCQs
Notes:
(i) Each Question has 4 points to choose from. Choose ONLY ONE point to answer the Question.
(ii) Answer the questions after carefully reading the text.
1- Caffeine is a member of:
a. Cerebral stimulants c. Spinal stimulants
b. Medullary stimulants d. None of the above
2- Caffeine produces its effect via:
a. Inhibiting PDE c. Both (a) & (b)
b. Blocking P1 receptor d. None of the above
3- Cardiovascular effects of theophylline include:
a. Stimulation of vasomotor center c. Direct vasorelaxation
b. Stimulation of vagal center d. All the above
4- Theophylline produces its diuretic effect via:
a. Increasing renal blood flow c. Inhibiting ADH release
b. Increasing glomerular permeability d. All the above
5- Xanthines may have the following digestive effect(s):
a. Increase gastric acidity. c. Irritate gastric mucosa.
b. Relax biliary muscle. d. All the above
6- The followings are indications for theophylline, except:
a. Bronchial asthma c. Biliary colic
b. Cardiac edema d. Hypertension
7- The followings are contra-indications for theophylline, except:
a. Gastric ulcer c. Biliary colic
b. Gout d. Hypertension
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