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PACOP PCOL questions with complete solutions.
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PACOP PCOL questions with complete solutions.
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PACOP PCOL questions with complete solutionsMechanism of action of local anesthetics Correct Answer-Block sodium channels thereby stopping axonal conduction
The ff are factors that affect the absorption of the drug from the GI tract EXCEPT: a. SA of site of absorption
b. blood flow
c. physical state of drug
d. conc of drug at absorption site
e. protein binding Correct Answer-E. protein binding
Continued stimulation of cells with agonists results to which of the ff: a. desensitization
b. up-regulation
c. down-regulation
d. A and B
e. A and C Correct Answer-E. A and C (desensitization and down-regulation)
Drug that lacks intrinsic efficacy but retains affinity and competes with the agonist for the binding site on the receptor Correct Answer-competitive antagonist
this type of drug produces its effect by binding a site on the receptor distinct from that of the primary agonist and thereby changing the affinity of the receptor for the agonist Correct Answer-non-competitive antagonist
In this type of study, participants are blinded to treatment assignment, but investigators are not. Correct Answer-single blinded study The neurotransmitter of all preganglionic autonomic fibers and all postganglionic parasympathetic fibers Correct Answer-Acetylcholine
the release of acetylcholine and other neurotransmitters by exocytosis is inhibited by Correct Answer-botulinum toxin
all of the ff enzymes are involved in the biosynthesis of epinephrine from tyrosine EXCEPT: a. tyrosine hydroxylase
b. aromatic L-amino acid decarboxylase
c. dopamine Beta-hydroxylase
d. phenylethanolamine-N-methyl transferase
e. monoamine oxidase Correct Answer-E. monoamine oxidase
Rate limiting enzyme in the synthesis of catecholamines Correct Answer-Tyrosine hydroxylase
All of the ff are effects of activating beta 2 receptor, EXCEPT: A. Bronchoconstriction
B. Uterine relaxation
C. Glycogenolysis
D. Gluconeogenesis
E. Bronchodilation Correct Answer-A. Bronchoconstriction
All of the ff are effects of activating alpha 1 receptor, EXCEPT: A. vascular smooth muscle relaxation
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