Exam (elaborations)
PCOL 390 Final Exam questions with correct answers
- Course
- Institution
PCOL 390 Final Exam questions with correct answers
[Show more]
Content preview
PCOL 390 Final Exam questions with correct answersThe most accepted definition for a drug is: Correct Answer-Any substance (other than food) that elicits a physiological effect and is used for therapeutic intent to prevent, alleviate, or cure illness.
The best definition for a Pharmacologist is: Correct Answer-A research scientist who seeks new knowledge of the source, physical and chemical properties, compounding, physiological actions, absorption, fate, and excretion, and therapeutic uses of drugs.
The best definition for a Pharmacist is: Correct Answer-A health professional with specialized training in preparing and dispensing prescription drugs.
Which of the following clinical trial phases typically enrolls the largest number of patients? Correct Answer-Phase 3.
Preclinical studies in drug development often include: Correct Answer-1. Drug discovery studies
2. In vitro cell-based studies
3. Live animal studies
Identify the FALSE statement(s)
- Cardiac glycosides can be found in plants and are an example of phytocehmicals
- Reports of self-medication in animals is limited to humans and non-human primates
- Mulberry Leaf extract is an FDA-approved over the counter medication
- Type 2 diabetes is due to the destruction of beta-cells of the pancreas - Drug dose-response curves are displayed in a log-linear (semi-log) format Correct
Answer-- Mulberry Leaf extract is an FDA-approved over the counter medication.
- Type 2 diabetes is due to the destruction of beta-cells of the pancreas.
With respect to the A1C test, choose all the TRUE statements:
- Provides a measurement of the 3-month average of an individual's blood ketone levels.
- Provides a measurement of the 3-month average of an individual's blood glucose levels.
- Measures the amount of glucose bound to hemoglobin in red blood cells.
- Measures the amount of glucose bound to myoglobin in muscle cells.
- All of the above are FALSE. Correct Answer-- Provides a measurement of the 3-
month average of an individual's blood glucose levels
- Measures the amount of glucose bound to hemoglobin in red blood cells
With respect to the Therapeutic Index (TI), choose the TRUE statement(s):
- ED50 refers to the dose that elicits an effective response in 50% of individuals
- TD50 refers to the dose that elicits a toxic response in 50% of individuals
- TI is the ratio of TD50/ED50
- TI is the ratio of ED50/TD50
- Overall, the greater the TI value is, the safer the drug is from toxic side effects Correct Answer-- ED50 refers to the dose that elicits an effective response in 50% of individuals
- TD50 refers to the dose that elicits a toxic response in 50% of individuals
- TI is the ratio of TD50/ED50 - Overall, the greater the TI value is, the safer the drug is from toxic side effects
Within an individual a drug undergoes a multi-phase life cycle. Which is NOT one of those phases. Correct Answer-Synthesis.
Routes of drug administration include: Correct Answer-- Intravenous (IV)
- Intramuscular (IM)
- Oral (PO)
- Subcutaneous (sc)
- Inhalation
(T/F) The hepatic portal system collects venous blood from the lower esophagus, stomach, duodenum, jejunum, ileum, colon, spleen and delivers it to the liver via portal vein. Correct Answer-True.
(T/F) The liver metabolizes xenobiotics delivered via the hepatic portal via "First Pass" metabolism. Correct Answer-True.
(T/F) Chondrocytes are the functional cells of the liver. Correct Answer-False.
Identify the TRUE statements regarding cytochrome P450s (CYP450).
- CYP450s are a large, highly polymorphic gene family of mixed-function oxygenases
- CYP450s play an important role in drug metabolism
- CYP450s can activate drugs to their biologically active form
- CYP450s can activate drugs to their biologically toxic form
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller Classroom. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
79650 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now