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samenvatting microcirculatie
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samenvatting van microcirculatie
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SAMENVATTING MICROCIRCULATIE 4 functies
1) Artriolair (weerstandvaten)
2) Veneus (capacitatie) => distributie bloedvolume
3) Passage & interactie leukocyten (inflamatie)
4) Uitwisseling
Door contractie van precapillairen sphinters kan bloed enkel door de hoofdbloedvat stromen naar
het hart (flow stopt van capilairen)
Rust: slecht 1 arteriolen gedilateerd voor O2 aanvoer naar de skeletspieren
Niet alle capillairen zijn in rust open
Inspanning: andere arterialen dilateren -> meer perfusie van de skeletspieren
! bloedcellen (rbc, wbc) moeten hervormen om door capillairen te passen (kleine diameter)
4 processen van transport door capillaire wand
1) Diffusie : 02,CO2, goed lipofiele moleculen -> door epitheelcel heen
2) Bulk flow: H20, elektrolyten & kleine moleculen -> door cel-cel adhesie
- weinig bij continu capillair
3) Pinocytose: macro-moleculen -> endo/exocytose van vloeistof
4) Actief transport: ionen, kleine moleculen -> via ATP pompen
Continu capillair: dichte hechtingen tussen endotheelcellen -> weinig bulkflow
Capillair met fenestraties: veel fenestraties of porien in endotheelcellen
- Bv: nier, darmmucose
Sinusoid: discontinu capillairen: hoge permeabiliteit door incompleet basaal membraan &
intercellulaire openingen
- Bv: Lever, beenmerg
WET VAN FICK: J = A x D x (delta C)/X => J = P x A x delta C
flux in mol/sec = diffusieconstante x oppervlakte x concentratieverschil/ afstandverschil
permeabiliteitsconstante: P = delta D/delta X
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