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Implants summary

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Pharmaeutical implants structural and drugs

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  • May 13, 2024
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  • 2023/2024
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Implants
ILOs: Understand the basic principles of medical/pharmaceutical implants ➢ Describe the
role of pharmacists in managing patients with implants ➢ Discuss the ideal properties of an
implant and their advantages/disadvantages ➢ Describe the common types of medical
implants
What is an implant?
 pharmaceutical device or tissue places inside or on the body
 temporarily or permanently
 many implants are prosthetics intended to replace missing body parts (structural)
 whereas other deliver medication
 support organs
 monitor body functions (functional)
Role of Pharmacists in managing patients with implants
 may need to prescribe one to a patient
 especially those that deliver medication
 may have adverse effects so you want to help the patient minimise risks
 patient education
o adverse effects
o potential complications
o importance of regimen
Ideal properties of an implant
 biocompatable: will create patient issues e.g. rejection
 easy to sterilise: unable to put inside a patient
 stable inside biological environment
o environment may be harsh
o we want them to stay for long periods
o don’t want their function to be compromised
o e.g. contraception implant for 3 years, if not stable patient won’t be
protected for pregnancy
 controlled and sustained release
o applies to implants that deliver drugs
o patient doesn’t want a spike in drug delivery
 good mechanical strength and flexibility
o may not be able to perform well without
o or won’t sit well in the body
 easy to insert inside the body
Advantages of implants
 patient compliance
o e.g. dementia patients who forget to take pills
o or contraceptive pikk must be taken same time each day, not applied for
implant
 convenience
o minimal maintenance once implanted
 long-lasting
o contraceptive implant can last 3 years
o structural hip replacements can last over 15 years

,  reduced side effects
o not passing through GI
o doesn’t pass through the first pass metabolism
o not all drug will end up in blood
o implant can control the release of drug straight into the blood
 outpatient treatment
o can leave once inserted
 improved efficacy
o due to controlled and sustained released
o due to reduced side effects
o stabilised conc in the blood
Disadvantages of implants
 specialist to insert
 surgical
 difficult to remove and need specialist
 limited drug compatibility
o not all drugs can be given via implant
 infection risk
 adverse reaction
o immune response
o rejection
o even if the implant is biocompatible
o doesn’t mean its immunogenic
 implant failure
How do we classify implants?
- Anatomy
- Purpose
- Function
- Material used
Functions of implants and give examples
 bio stimulation
o bone grafts: promote bone growth and healing
o dental implants: replace missing tooth roots and support dental crowns
o cartilage repair: support cartilage regeneration in joints
 drug delivery
o hormonal
o pain management
o insulin
 neurostimulatory
o deep brain stimulation: treat neurological disorders e.g. Parkinsons by
stimulating specific brain regions
 holes in the skull
 insert electrodes
 electrical impulse
 target areas of the brain
o spinal cord stimulation: pain relief
o vagus nerve stimulation: epilepsy and depression

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