CDE EXAM 202 4 QUESTIONS AND ANSWERS WITH SOLUTIONS Biguanides Medication Names - ANSWER Metformin (Glucophage, Riomet (Liquid)) Metformin Extended Release (Glucophage XR, Fortamet, Glume tza) Biguanides Medication Action (oral) - ANSWER Decreases amount of glucose released from liver. lowers A1c up to 2% Biguanides Possible Side Effects - ANSWER Bloating, gas, diarrhea, upset stomach, loss of appetite (usually within the first few weeks of starting). Take with food to minimize symptoms. Metformin is not likely to cause low blood glucose. In rare cases, lactic acidosis may occur in people with abnormal kidney or liver function. Metformin increases the sensitivity of insulin Sulfonylureas Medication Action (oral) - ANSWER Stimulates the pancreas to release more insulin, both right after a meal and then over several hours Sulfonylureas Medication Names - ANSWER Glimepiride (Amaryl) Glyburide (Diabeta, Micronase) Glipizide (Glucotrol, Glucotrol XL) Micronized Glyburide (Glynase) lower a1c up to 2% Sulfonylureas Possible Side Effects - ANSWER Low blood glucose, occasional skin rash, irritability, upset stomach Meglitinides & D-Phenylalanine Derivatives Medication Action (oral) - ANSWER Stimulate the pancreas to release more insulin right after a meal. Meglitinides & D-Phenylalanine Derivatives Medication Names - ANSWER Re paglinide (Prandin) Nateglinide (Starlix) Meglitinides & D-Phenylalanine Derivatives Possible Side Effects - ANSWER Effects diminish quickly and they must be taken with each meal; may cause low blood glucose Thiazolidinediones Pioglitazone (TZDs) Med ication Action (oral) - ANSWER Makes the body more sensitive to the effects of insulin. Increases the amount of glucose taken up by muscle cells and keeps the liver from overproducing glucose Thiazolidinediones Pioglitazone (TZDs) Medication Names - ANSWE R Pioglitazone(Actos) Rosiglitazone (Avandia) Thiazolidinediones Pioglitazone (TZDs) Possible Side Effects - ANSWER May cause side effects such as swelling (edema) or fluid retention. Do not cause low blood sugar when used alone. Increased risk of congestive heart failure in those at risk. mobilize visceral fat and promote deposition in sub q adipose tissue Dipeptidl Peptidase 4 Inhibitors (DPP -4) Medication Action (oral) - ANSWER Incretin tells your body to release insulin after you eat. After the insulin is released, an enzyme called DPP -4 remove s the incretin from the body - these inhibit DPP -4 removal so incretin stays and triggers more insulin to be released Dipeptidl Peptidase 4 Inhibitors (DPP -4) Medication Names - ANSWER Sitagliptin (Januvia) Saxagliptin (Onglyza) Linagliptin (Tradjenta) Alopliptin (Nesina) Dipeptidl Peptidase 4 Inhibitors (DPP -4) Possible Side Effects - ANSWER Stomach discomfort, diarrhea, sore throat, stuffy nose, upper respiratory infection. Do not cause low blood glucose. Alpha -glucosidase (Carbohydrate) Inhibitors Med ication Action (oral) - ANSWER Slows the absorption of carbohydrate into your bloodstream after eating. Alpha -glucosidase (Carbohydrate) Inhibitors Medication Names - ANSWER Acarbose (Precose) Miglitol (Glyset) Alpha -glucosidase (Carbohydrate) Inhibitors Possible Side Effects - ANSWER Gas, diarrhea, upset stomach, abdominal pain Bile Acid Sequestrants Medication Action (oral) - ANSWER Primary effects to lower LDL cholesterol; -prevent resorption of bile acids from small intestine -bile acids are necessary for absorption of cholesterol
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