BCH462 Quiz 6 Exam Questions With 100% Correct Answers
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Course
BCH 462
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BCH 462
BCH462 Quiz 6 Exam Questions With 100%
Correct Answers
Hormones bind to _ via _ - answerreceptors, high affinity non-covalent interactions
A small molecule produced inside a cell in response to a hormone binding to its receptor is called
a(n) _. An example would be _ produced in response to epi...
BCH462 Quiz 6 Exam Questions With 100% Correct Answers Hormones bind to _ via _ - answer✔✔receptors, high affinity non -covalent interactions A small molecule produced inside a cell in response to a hormone binding to its receptor is called a(n) _. An example would be _ produced in response to epinephrine binding. - answer✔✔second messenger, cAMP Activation of a G protein in response to hormone binding requires binding of _ to the _ subunit - answer✔✔GTP, alpha What enzyme is activated when directly interacting with an active G protein? Group of answer choices - answer✔✔adenylate cyclase In response to glucagon, the second messenger _ is produced by the enzyme _. - answer✔✔cAMP, adenylate cyclase Activation of protein kinase A occurs by binding of _ to each _ subunit. Protein kinase A will phosphorylate _ and _. - answer✔✔2 molecules of cAMP, regulatory, serine, threonine Which of the following explains the activities of adenylate cyclase and cAMP phosphodiesterase? - answer✔✔when glucagon is bound to receptor, the activity of adenylate cyclase is much greater than the activity of cAMP phosphodiesterase Use the dropdown menus to arrange the following events for the termination of the response in the 𝛽-adrenergic receptor. - answer✔✔1. hormone dissociates from receptor 2. GTP hydrolyzed by the G TPase activity of the G 𝛼 subunit 3. G𝛼 subunit dissociates from adenylate cyclase 4. G𝛼 subunit binds to 𝛽 and 𝛾 subunits The 𝛽-adrenergic receptor can be removed from the membrane by first _ which allows _ that facilitates _. - answer✔✔phosphorylati on by BARK, association with B -arrestin, sequestration of the receptor in a vessicle Activity of the Ras protein is analogous to _____ in terms of its ability to bind GTP. - answer✔✔the G protein 𝛼 subunit Epinephrine has the following structure: Picture Most drugs that are able to bind to the epinephrine receptor contain an amine group and a hydroxyl group that appear red in the above structure of epinephrine. The most prevalent interactions between epinephrine and its receptor are _ and _ - answer✔✔an el ectrostatic interaction with Asp, a hydrogen bond with Ser The Ras protein forms hydrogen bonds with the terminal phosphate of GTP. One hydrogen bond is made with a glycine residue. What part of the glycine residue must be involved in the hydrogen bond? Group of answer choices - answer✔✔the hydrogen of the amide group Consider the inactive protein kinase A structure. Binding of cAMP occurs on the _ subunits of protein kinase A. Each inactive protein kinase A complex must bind _ cAMP, thus releasing _ active protein kinase A enzymes. - answer✔✔regulatory, 4, 2 Activity of the G -protein pathway is inactivated by the _ activity of the G -protein and the activity of cyclic nucleotide phosphodiesterase that hydrolyzes _ - answer✔✔GTPase, cAMP Phospholipase C is activated by _ which causes the _ of _. - answer✔✔binding of Ga, hydrolysis, phosphatidylinositol -4,5 biphosphate One product of phospholipase C, _ binds to a _ channel on the _. This results in a/an _ in the concentration of the ion in the cytosol. - answer✔✔inositol -1,4,5 -triphosphate, calcium ion, endoplasmic reticulum membrane, increase The other product of phospholipase C, _ moves through the _ in order to activate _. - answer✔✔diacylglycerol, cell membrane, protein kinase C The ____ _ receptor is a receptor tyrosine kinase. - answer✔✔insulin Insulin binding to its receptor results in _. As a result, tyrosine residue are _. This allows for interaction with _. - answer✔✔receptor dimerization, phosphorylated, IRS -1 In the non -phosphoryla ted tyrosine kinase domain, the activation loop blocks the substrate binding site due to _. Once phosphorylated, _ causes the activation loop to vacate the substrate binding site. - answer✔✔hydrogen bond between Tyr and Asp, repulsion of negatively charge Asp and phosphotyrosine The tyrosine kinase domain of the insulin receptor phosphorylates _ which activates _. - answer✔✔IRS-1, kinase activity of phosphoinositide -3-kinase When the insulin signalling cascade is activated, the Ras protein must be _ and be localized to the cell membrane. Membrane localization of H -Ras is accomplished by the relatively permanent addition of a _ group to a Cys residue via a _ and the reversible addition of one or more _ groups to a _ residue via a _. K -Ras, which contains a hi gh lysine content, is associated with the
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