NR 507 Advanced Patho Midterm Study Guide Questions & Correct Answers/ Graded A+

Infectivity : The ability of a pathogen to invade and multiply in the host. Anemia : Most common blood disorder in children Hemolytic Anemia's of Newborns : Are Inherited, Congenital, or Both Hemolytic Disease of the Newborn (HDN) : Also called Erythroblastosis fetalis HDN : Alloimmune disorder in which maternal blood and fetal blood are antigenically incompatible causing the mother's immune system to produce antibodies against fetal erythrocytes. 2 Iron Deficiency Anemia : most common blood disorder of infancy and childhood with highest incidence between 6 months and 2 years old Inactive MLH1 and Inherited Colon Cancer : A major cause of one form of inherited colon cancer (hereditary nonpolyposis colorectal cancer [HNPCC]) is the methylation of the promoter region of a gene, MLH1, whose protein product repairs damaged DNA. When MLH1 becomes inactive, damaged DNA accumulates, eventually resulting in colon tumors. Conditions where inflammation is etiology of Cancer : INFLAMMATORY CONDITION ASSOCIATED NEOPLASM(S) Asbestosis, silicosis-Mesothelioma, lung carcinoma Bronchitis-Lung carcinoma Cystitis, bladder inflammation-Bladder carcinoma Gingivitis, lichen planus-Oral squamous cell carcinoma Inflammatory bowel disease, Crohn disease, chronic ulcerative colitis-Colorectal carcinoma Lichen sclerosus-Vulvar squamous cell carcinoma Chronic pancreatitis, hereditary pancreatitis-Pancreatic carcinoma Reflux esophagitis, Barrett esophagus-Esophageal carcinoma 3 Sialadenitis-Salivary gland carcinoma Sjögren syndrome, Hashimoto thyroiditis-MALT lymphoma Skin inflammation-Melanoma Chronic inflammation predisposes one to ______________. : Cancer Organs susceptible to Oncogenic effects of chronic inflammation : the gastrointestinal (GI) tract, prostate, thyroid gland, pancreas, urinary bladder, pleura, and skin. Factors that contribute to development of cancer : •Lifestyle choices, such as nutritional intake, smoking, or alcohol use •Environmental conditions, including exposure to sunlight, natural and medical radiation, workplace exposures, and involuntary or unknown exposures •Lack of physical exercise and overweight/obesity •Sexual practices •Prescribed and illicit medications •Socioeconomic factors that affect exposures and susceptibility •Carcinogenic substances present in air, water, an