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Immunology Kuby Chapter 8 The Major Histocompatibility Complex and Antigen
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Immunology Kuby Chapter 8 The MajorHistocompatibility Complex and Antigen
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1 - ANS-Viruses are able to shut down the expression of MHC Class ___.
1. MHC molecules:
A. are secreted by T cells and bind and neutralize antigen in the serum.
B. are membrane-bound molecules found exclusively on T cells.
C. bind repeating patterns found on pathogens.
D. are recognized by T cells.
E. are conserved between individuals. - ANS-Answer: D
Section: The Structure and Function of MHC Molecules
Difficulty: 1
Hint: MHC molecules present foreign peptides.
10. Your chances of having the same MHC haplotype as your sibling are:
A. 1:1.
B. 1:2.
C. 1:4.
D. 1:8.
E. 1:16. - ANS-Answer: C
Section: General Organization and Inheritance of the MHC
Difficulty: 2
Hint: MHC Class I is codominantly expressed.
11. The human MHC locus is one of the most polymorphic regions of the genome. What
does this mean?
A. It has the most different genes.
B. There are many different alleles of these genes.
C. Sequence variability is low in this region.
D. There are many introns in this region.
E. This region is regulated by many different mechanisms. - ANS-Answer: B
Section: General Organization and Inheritance of the MHC
, Difficulty: 2
Hint: Polymorphisms are genetic variants that result in phenotypic differences.
12. MHC diversity ultimately affects the:
A. variety of peptides that bind to MHC.
B. variety of BCRs that are expressed on mature B cells.
C. rate of somatic hypermutation.
D. number of antigen presenting cells.
E. transmembrane domain. - ANS-Answer: A
Section: General Organization and Inheritance of the MHC
Difficulty: 1
Hint: MHC diversity is located primarily in the peptide-binding groove.
13. Which of the following BEST represents the relationship of polypeptide units in MHC
class II?
A. α and β chains from any gene can pair with each other.
B. Only α and β chains from the same gene can pair with each other.
C. Only α and β chains of the same allele can pair with each other.
D. α chains can pair with other α chains, but β chains can only pair with α chains.
E. α and β chains pair until the complex is exported to the cell surface and can bind β-2
microglobulin. - ANS-Answer: B
Section: General Organization and Inheritance of the MHC
Difficulty: 2
Hint: There are four different class II molecules for each gene that can be produced in a
heterozygote.
14. Tasmanian devils are a largely inbred population with little diversity in the MHC.
Which of the following would be a likely outcome of this?
A. They would compensate for low diversity in the MHC with high diversity in the TCR.
B. They would compensate for low diversity in the MHC with high diversity in the BCR.
C. They would rely only on innate immune responses.
D. They would be at higher risk of infection.
E. All of the above - ANS-Answer: D
Section: General Organization and Inheritance of the MHC
Difficulty: 2
Hint: Low diversity in the MHC would result in an immunodeficient population.
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