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APEA PRE-PREDICTOR EXAM LATEST ACTUAL EXAM 400+ QUESTIONS AND ANSWERS EXAM NEWEST 2024 ACTUAL EXAM 400+ QUESTIONS AND CORRECT DETAILED ANSWERS VERIFIED ANSWERS ALREADY GRADED A+ $19.49
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APEA PRE-PREDICTOR EXAM LATEST ACTUAL EXAM 400+ QUESTIONS AND ANSWERS EXAM NEWEST 2024 ACTUAL EXAM 400+ QUESTIONS AND CORRECT DETAILED ANSWERS VERIFIED ANSWERS ALREADY GRADED A+
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A 15 years old high school student with a mild sore throat and low-grade fever that has persisted for about 3 weeks. She reports general malaise, fatigue, and loss of appetite. The NP suspects mononucleosis. Which of the following is the LEAST appropriate intervention? Palpate the lymph n...

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  • June 6, 2024
  • 29
  • 2023/2024
  • Exam (elaborations)
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  • apea pre predictor exam latest actual exam 400
  • apea pre predictor exam latest actual exam 400
  • apea pre predictor exam latest actual exam 40

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NMTCB PET certification Review 2023 -2024 questions with correct answers GRADED A Rb-82 Gener taor Alert Level - ✔✔ 14L of eleute volume reached, or Sr -82 level 0.002uCi/mCi of Rb -82, or Sr -85 level 0.02uCi/mCi of Rb -82 Actions for Rb82 Generator Alert Level - ✔✔ Test after every 750 mL has passed through generator Stop using Rb -82 generator if - ✔✔17L of eleute volume reached, or 42 days post calibration date, or Sr82 levenis 0.01uCi/mCi of Rb82, or Sr85 level reaches 0.1uCi/mCi of Rb82 Cyclotron produced isotopes and half -life - ✔✔ C11, 20.3 min; N13 9.97 min; O15 2.03 min; F18, 109.7 min Advanta ges of negative ion cyclotrons - ✔✔ 1) less nuclear activation of cyl potion cavity and surroundings, 2) can self -focus beam of particles, 3) can irradiate 2 targets at once Isotopes produces by negative ion cyclotrons - ✔✔ C, N, O = metabolites Reaction f or chemical labeling of F18 -FDG - ✔✔ Nucleophilic substitution Chemical reaction of FDG - ✔✔ Electron rich group of atoms change place on molecule with a positively charged leaving group Precursor molecule for FDG - ✔✔ Mannose triflate Chem formula of FDG - ✔✔ 2-deoxy -2-[18F]fluoro -D-glucose. (Fludeoxyglucose F -18) Intermediate step in FDG synthesis - ✔✔ Alkaline hydrolysis of 4 acetyl groups by replacing with OH Size filter used after purification - ✔✔ 0.22 um FDA ref for PET pharma pro duction - ✔✔ General chapter 823 FDG QA appearance - ✔✔ Colorless liquid FDG QA radiochemical identity - ✔✔ Thin -layer chromatography Rf value to reference standard FDG QARadionuclide identity - ✔✔ Half-life 105 and 115 minutes FDG QA bacterial endotoxins test - ✔✔ LAL (Limulus amebocyte lysate) <175 USP endotoxins units per max volume injection; endotoxins< 17.5 EU FDG QC pH - ✔✔ Between 4.5 to 7.5 FDG QA Radiochemical purity - ✔✔ Thin -layered chromatography radioactive Rf should be not less than 90% of tot al radioactivity of chromatography plate FDG QC Radionuclideic purity - ✔✔ should be >99.5% of radionuclidie specified. tested using multi -
channel analyzer with peaks at 0.511 and 1.022 MeV FDG QC chemical purity - ✔✔ testing depends upon synthesis method used to create FDG Kryptofix 222 - ✔✔ FDG QC chemical purity test - thin-layer paper chromatography spot test. 50 ug/mL and FDG solution must demonstrate a less intense response than standard 2-Chloro -2-deoxy -D-glucose - ✔✔ FDG QC chemical purity test used if hydrolysis step was performed with hydrochloric acid. Use high -performance liquid chromatography using an electrochemical detector. Mus not have more than 1 mg CLDG: 2 -deoxy -2-D-glucose FDG QC Residual solvents - ✔✔ solvents can be in FDG from cleaning or synthesis solutions. solutions may contain acetonitrle, ether anddehydrated alcohol. no more 0.04% acetonitrle, and less than 0.5% of ether or ethanol FDG QC Sterility - ✔✔ not performed before dosing due to need of 14 days to perform. Regulations require final produce to be placed in soy broth mixture with a thioglycollate growth media for 30 hrs. look for observable bacteria FDG QC Filter membrane integerity - ✔✔ final sterility filter u sed at end of manufacturing process. Filter must remain intact as pressure increased to 50 psi (bubble point test) FDG synthesis room requirements - ✔✔ room: cGMP, ISO class 5 clean room air hood, 21 CFR 212 for manufacturing of IV drugs which radiouclide s are possible radioactive contaminates in eluent of Rb82 generators - ✔✔ Sr82 and Dr85 negative ion PET cyclotrons accelerate which partiles - ✔✔ negatively charged hydrogen atoms chemical method used to label F18 to glucose - ✔✔ nucleophilic substitution

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