Multiple Myeloma Exam With Verified Solutions
Multiple Myeloma is a malignancy of _________ cells
plasma
T or F: MM is the most common hematologic malignancy in the US.
False, 2nd most common after non-hodgkin's disease
Which ethnicity has a 2x incidence of MM?
African Americans
...
Bacterial Infections
-Depleted T lymphocytes and non-functional IgG
"Myeloma Kidney"
-50% patients have increased CrCl
-caused by hypercalcemia, hyper viscosity,hyperuricemia
List two complications of Myeloma
1. Bone disease
, -stimulated osteoclasts and bone breakdown
RANKL and inflammatory mediators upregulated
2. Angiogenisis: increase in blood vessel density can use PCLI is predict increased density
High plasma cell labeling index (PCLI)
Increased angiogenesis
-> increased blood thickness
List Diagnostic tests for MM
CBC with diff
CMP: Ca, SCr,BUN,LDH,albumin
Bone marrow biopsy
*B2-microglobulin (Ig heavy chain)*
MRI, bone scan
Serum Protein electrophoresis
*identify M spike-85% patients**
Which prognosis/risk cytogenetic mutation occurs in ~65% of MM patients?
chromosome 14 mutation which leads to Ig heavy chain translocation
List the disease progression of MM
Normal plasma cell
MGUS
(Monoclonal gammopathy of undetermined significance)
Smoldering/indolent myeloma
multiple myoloma
Which diagnostic criteria is used most commonly in active (symptomatic myeloma)?
Lytic bone lesions: parts of bone are punched out by cancer
CRAB criteria
What does CRAB stand for?
Calcium
Renal dysfunction
Anemia
Bone
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller ACADEMICAIDSTORE. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $10.69. You're not tied to anything after your purchase.
