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Foundations CBR20 – Toxicology Exam Questions With Complete Solution

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Foundations CBR20 – Toxicology Exam Questions With Complete Solutions How does activated charcoal work for decontamination and how should it be administered? High surface area binding to toxin and preventing systemic absorption. Dose: 10:1 (10g AC per 1g drug) When is activated charcoal contraindicated or ineffective? Contraindicated in AMS/obtunded patient, risk of seizure or aspiration, ileus. Ineffective for pesticides, lithium, hydrocarbons, heavy metals, alcohols, caustics. How does whole bowel irrigation work for decontamination and how should it be administered? Iso-osmotic agent (e.g. Go-Lytely) taken in large volume will hasten progress through intestines and prevent absorption; Dose: 1-2L/hr (adults) or 500mL/hr (kids), consider giving by NGT, and continue until clear rectal effluent is produced. Think about using this for "drug packers" and also for ER beta-blockers. For what types of ingestion is whole bowel irrigation most effective? Iron, lithium, sustained-release formulations, enteric-coated meds, body packers What toxins are cleared by HD? "I STUMBLE": Isopropyl alcohol, Salicylate (aspirin), Theophylline, Uric acid, Methanol, Barbiturates/Beta-blockers, Lithium, Ethylene glycol Review the general pathophysiology, Dx, and Tx of Acetaminophen (APAP) overdose APAP normally broken down via sulfation & glucuronide conjugation. Small amount is broken down by CYP450 enzymes → toxic NAPQI metabolite. APAP OD: overloads glutathione inactivation/metabolism → excess NAPQI accumulates → liver toxicity. Dx: can use acetaminophen nomogram for SINGLE, ACUTE ingestions; get APAP level at ≥ 4 hours ( 4 hours NOT useful, unless ZERO). High risk of toxicity: 150mg/kg (acute) or 4g/day (chronic). Rx: N-acetylcysteine (NAC) → restores glutathione, acts as an antioxidant; best if given w/in 8 hours of ingestion; Dose PO (140mg/kg load, 70mg/kg q4hr) or IV (150mg/kg load, 50mg/kg over 4hr, 100mg/kg over 16hr). Safe for pregnant woman and children. Side effect: anaphylactoid reaction. When can you use the Rumack-Matthew nomogram for acetaminophen toxicity? For single acute ingestions, not for chronic ingestions. For chronic you treat based on acetaminophen level or signs of acute toxicity Review the general pathophysiology, Dx, and Tx of NSAID overdose COX inhibitor decreases prostaglandin production. SSx: minimal toxicity but can cause GI upset (rarely GI Bleed); large doses: AMS/ataxia, coma, metabolic acidosis, seizure. Rx: supportive. Review the general pathophysiology, Dx, and Tx of Aspirin (ASA) overdose Causes primary respiratory alkalosis (stimulates resp. center, EARLY, uncouples oxidative phosphorylation (AG metabolic acidosis, hyperthermia). SSx: ↑ RR, ↑ temp, ↑ HR (sinus tach = MC sign), tinnitus, vertigo, AMS, seizure. Rx: GI decon, urine alkalinization with bicarb (+K, +Mg) infusion (enhances urinary excretion of salicylate, also prevents CNS distribution), HD (acute level 100, chronic level 60, OR there is a presence of renal failure, severe acidemia, or pulmonary/cerebral edema. *If you intubate, you must set high RR or the acidemia will worsen and the pt will arrest.* Review the general pathophysiology, Dx, and Tx of opioid overdose Analgesic causing respiratory depression and impaired consciousness. SSx (TRIAD): CNS depression + respiratory depression + miosis (pinpoint pupils). Rx: naloxone (start low dose to avoid withdrawal & vomiting, uncomfortable but not life-threatening except in neonates) Review unique clinical complications for meperidine, tramadol and methadone Meperidine: seizures, serotonin syndrome, often dilated pupils. Tramadol: seizures, serotonin syndrome, anticholinergic effects (mydirasis). Methadone: QT prolongation (& TdP), hypoglycemia. What types of opioids are NOT seen on urine tox screen? Synthetics. Includes fentanyl, hydromorphone, buprenorphine, methadone, meperidine. Natural derivatives will show up (heroin, morphine, codeine, hydrocodone, oxycodone). What is the potential risk of using meperidi

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Foundations CBR20 – Pediatrics Exam
Questions With Answers Graded A+
Neonatal jaundice w/in 24hrs of life
BAD sign, ABO incompatibility, Rh incompatibility, TORCH infections, G6PD def. Admit, hydrate and
order Coombs test.


Neonatal jaundice 24hr-72hrs
Physiologic (indirect hyperbili), sepsis, others


Neonatal jaundice > 72 hrs
sepsis, breast milk jaundice, breast feeding jaundice, Gilberts. Remember, breast feeding jaundice:
suboptimal supply of breast milk, requires hydration and supplementation. Breast Milk jaundice is
when the baby's liver is not developed enough to handle breaking down the supply of breast milk
from mom.


Asian baby age 1 month with jaundice and direct hyperbile
Biliary atresia - dx of intra and extrahepatic bile ducts leading to obstructive jaundice, cirrhosis, and
death. Typically diagnosed before 2months ago. Tx: surgery w/ Kasai procedure.


Baby with conjugated hyperbili
*Will require admission and work up*. DDx: biliary atresia, SEPSIS, cholelithiasis, cystic fibrosis,
Wilson's, etc ...


What are the most concerning (and unique) causes of abdominal pain in the following age groups: 0-
3mo, 3mo-2yr, school aged kids
0-3mo: Necrotizing Enterocolitis, Hirschprung's/Toxic Megacolon, Volvulus, Pyloric Stenosis; 3mo-2yr:
Intussusception, Meckel's Diverticulum, Foreign Bodies; School age: similar to adults including
pregnancy (consider if >8)


Dx and Tx of Necrotizing Enterocolitis
Inflammation & necrosis of the bowel wall from translocaiton of gut bacteria; prematurity(greatest
risk factor); SSx: bilious emesis, bloody stools, abdominal wall erythema; Dx: XR with pneumatosis
intestinalis (pathognomonic), portal vein air (poor prognosis); Rx: IVF, broad spectrum antibiotics, NG
tube (bowel rest), surgery consult, admit


Dx and Tx of Hirschsprung Disease
Lack of ganglion cells in the rectosigmoid colon; SSx: Delayed passage of meconium (>48 hr) →
obstruction & bilious emesis (late finding); Complications: enterocolitis/toxic megacolon; Dx: rectal
biopsy (gold standard), contrast enema (transition zone); Rx: surgery, admit


Dx and Tx of Midgut Volvulus
1st mo of life; Congenital malrotation → volvulus → midgut ischemia; SSx: bilious vomiting (always
emergent), abd pain/distention, ± rectal bleeding/hematochezia (gut ischemia); XR "double bubble"
can also be seen in duodenal atresia; Dx (definitive): upper GI series "corkscrew", US; Rx: NGT, surgery
consult. Associated conditions: congenital diaphragmatic hernia, congenital heart disease,
omphalocele

, Dx and Tx of Intussusception
6mo-3yr; telescoping of bowel (ileoceal most common); Tumor, Meckel's, post-viral, HSP; SSx: colicky
abd pain w/ LETHARGY + abd mass (sausage-shape in RUQ; RLQ usually empty) + "currant jelly" stools;
AXR: obstruction, Dance's sign (pathognomonic); Dx (preferred): US "target sign"; Rx: OR (sick),
air/contrast enema (not sick), abx


Dx and Tx of Meckel Diverticulum
Most common congential GI malformation. Incomplete closure of vitelline duct → heterotopic gastric
mucosa; SSx: painless rectal bleeding 2/2 ulceration → obstruction (2/2
intussusception/volvulus/hernia; Rule of 2s: 2% of population, 2% symptomatic, 2ft proximal to
terminal ileum, 2x more often in males, 2yo most common; Dx: Meckel scan; Rx: surgical consult


Where do ingested foreign bodies usually get stuck?
Cricopharyngeus C6 (60-80%), GE junction T11 (10-20%), Aortic Arch T4 (5-20%); Coin most common
object swallowed. CXR (AP): coin appears flat if in esophagus


What are indications for emergent endosocopy for ingested foreign body?
High-grade obstruction, object in esophagus >24hr, object >6cm, sharp objects, multiple objects
swallowed, button battery in esophagus, button battery in stomach >48hr or if symptomatic (earlier)


Dx and Tx of Pyloric Stenosis
Age 2-8 wks. Hypertrophied pylorus. Most common congenital GI disorder. Risk factors: first-born
males, macrolide abx exposure. SSx: nonbilious projectile vomiting, "hungry vomiter"; Labs: hypoCl,
hypoK, metabolic alkalosis (2/2 vomiting), dehydration. Exam: palpable "olive-shaped" mass. Dx: US
(target sign), upper GI series "string sign". Rx: IVF, surgery


What is the most likely location of traumatic C-spine injury in young children?
Age < 8yrs more susceptible to upper cervical spine injuries (C1-3).


What are normal variants in pediatric c-spine imaging?
Pseudosubluxation (C2 on C3), growth plates can look like fractures, anterior wedging


What is SCIWORA?
"Spinal cord injury without radiographic abnormalities." May present with missed old injury leading to
significant subsequent injury after relatively minor trauma. XR/CT without abnormalities, MRI will
show problem area. Most commonly seen in children and the elderly.


Review common causes of anemia in young children
Physiologic nadir (Hgb 9 at 6wks), B12/folate deficiency (high MCV, hypersegmented polys, seen in
vegans), Iron deficiency (1-2yr, low MCV, associated with pica, breath holding, high milk intake (more
than 28-32 ounces per day), Sickle Cell dz (hemolysis, high retic count), Lead Poisoning (basophilic
stippling, abd pain, AMS)


Approximate weight for newborn, 1yr, 5yr, 10yr
Newborn: 3.5kg, 1yr: 10kg, 5yr: 20kg, 10yr: 40kg


How do you determine ETT size, depth, and blade size in young children?

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