ASCP Hematology Exam-MLT
A blood sample from a patient with a high titer cold agglutinin, which of the
following results can occur in the presence of a cold agglutinin?
A. increased MCV and decreased RBC
B. increased MCV and normal RBC
✅✅
C. decreased MCV and increased MCHC
D. decreased MCV and RBC - -D. MCV and RBC
A characteristic morphologic feature in hemoglobin C disease is:
A. macrocytosis
B. spherocytosis
✅✅
C. rouleax formation
D. target cells - -D. target cells
A common source of interference in the cyanmethehemoglobin method is:
A. hemolysis
B. very high WBC count
✅✅-B. very high WBC count
C. cold agglutinins
D. clumped platelets -
A patient has a congenital nonspherocytic hemolytic anemia. After exposure to
anti-malarial drugs, the patient experiences a severe hemolytic episode. This
episode is characterized by red cell inclusions caused by hemoglobin
denaturation. Which of the following conditions is most consistent with these
findings?
A. G-6-PD deficiency
B. thalassemia major
✅✅-A. G-6-PD deficiency
C. pyruvate kinase deficiency
D. paroxysmal nocturnal hemoglobinuria -
, A patient has a high cold agglutinin titer. Automated cell counter results reveal an
elevated MCV, MCH, MCHC. Individual erythrocytes appear normal on a stained
smear, but agglutinates are noted. The appropriate course of action would be to:
A. perform the RBC, Hgb, Hct determinations using manual methods
B. perform the RBC determination by a manual method; use the automated
results for the Hgb and Hct
C. repeat the determinations using a microsample of diluted blood
✅✅
D. repeat the determinations using a prewarmed microsample of diluted blood -
-D. repeat the determinations using a prewarmed microsample of diluted
blood
A patient has the following laboratory results:
RBC: 2.00 x 10^6/uL (2.00 x 10^12/L)
Hct: 24%
Hgb: 6.8 g/dL (68 g/L)
Reticulocytes: 0.8%
The mean corpuscular volume (MCV) of the patient is:
A. 35 um^3 (35 fL)
B. 83 um^3 (83 fL)
✅✅-C. 120 um^3 (120 fL)
C. 120 um^3 (120 fL)
D. 150 um^3 (150 fL) -
A red blood cell about 5 um in diameter that stains bright red and shows no
central pallor is a:
A. spherocyte
B. leptocyte
✅✅-A. spherocyte
C. microcyte
D. macrocyte -
A screening test for paroxysmal nocturnal hemoglobinuria is:
A. heat instability test
B. sucrose hemolysis
C. osmotic fragility
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