ASCP BOC Hematology
____________ and ____________ are required for heme synthesis - ✅✅-iron
and protoporphyrin
✅✅
A rare condition in which the body stops producing enough new cells -
-aplastic anemia
Basophilic stippling is composed of - ✅✅-RNA
Clinical correlations: dry tap may mean - ✅✅-aplastic anemia, myelofibrosis
Dhole bodies are associated with - ✅✅-bacterial infections, burns, may hegglin
anomaly
EDTA chelates ____ - ✅✅-Calcium
✅✅
Excess iron that is stored in tissues and body organs can lead to ____________
and ____________ - -hemosiderosis and hemochromatosis (organ
damage)
Fe Transport protein - ✅✅-Transferrin
H2O insoluble Fe storage form (long-term) - ✅✅-hemosiderin
H2O insoluble Fe storage form (long-term) - ✅✅-Hemosiderin
Heinz bodies are composed of - ✅✅-denatured hemoglobin
Heparin is an ______________________ - ✅✅-anti-thrombin agent
Howell-Joly bodies are composed of - ✅✅-DNA
Hypersegmented neutrophils are associated with - ✅✅-megaloblastic anemia,
B12 and folate deficiency
, Hyposegmented neutrophils are associated with - ✅✅-pelger huet anomaly
(AML, AIDS)
Major Fe storage form -✅✅-Ferritin
Mature RBC lack what organelle? - ✅✅-mitochondria
Measures packed cell volume in a percent - ✅✅-hematocrit
Oval macrocytes are seen mostly in... - ✅✅-megaloblastic anemia
Pappenheimer bodies/siderotic granules are composed of - ✅✅-Iron
Splenomegaly can lead to - ✅✅-anemia and leukopenia
Toxic granulation and vacuoles are associated with - ✅✅-bacterial infection,
burns, chemo
Variant lymphs are associated with - ✅✅-IM, viral infection
What abnormal RBC is a sign of extramedullary hematopoeisis? - ✅✅-teardrop
cells
What are some sources of error for hemoglobin? - ✅✅-icterus, lipemia,
hemolysis, increased white count
What are some sources of error from a calculated hematocrit? - ✅✅-cold
agglutinins, high white count
What are the hematocrit reference ranges for men and women? - ✅✅-male: 47
+- 5 %
women: 42 +- 5%
What are the heme precursors (in order) - ✅✅-Delta, Porphobilinogen, UR,
COP, PROTO
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