of thera- py/quantity, pt Ax, date of Rx, route, signature, DEA #
4. "Rational" Prescribing Process, WHO: Choose a rational
,treatment Selection of P-drugs (Personal drugs)
Treating the pt (select, Rx,
monitor) Keeping up-to-date
5. What are P-drugs?: P(ersonal) drugs - those that you are going to
prescribe regularly and with which you become familiar
6. Steps of Rational Prescribing: Define the pt's
problem Specify the therapeutic objective
Choose Tx
Verify: efficacy, safety,
suitability, cost Start Tx (write a
clear Rx)
Educate! Give inform instructions,
warnings Monitor treatment
7. What is DAW in prescribing?: Dispense as written
8. "Rights" of a prescription:
Patient Medication
Dose
Rout
e
,Dose schedule
Does this make sense for this drug, patient, situation?
9. Pharmacokinetics: How the body affects a drug
10.Pharmacodynamics: How a drug affects the body - effects that
occur at the cellular and systemic levels
11.Pharmacogenomics: General study of how one's individual genetic
variation affects drug behavior
, 12.Four components of pharmacokinetics: ADME - absorption,
distribution, me- tabolism, excretion
13.Absorption: How (well) does the body uptake the drug?
14.Distribution: Transportation of the drug to the site of
action How (well) is the drug carried to the site of
action?
15.Elimination: How (well) is the drug cleared from the body?
16.All types of absorption are affected by...: Drug properties (molecular
weight, lipid solubility) pKa, drug formulation, disintegration time,
dissolution rate)
17.Enteral Absorption - GI tract - affected by? (4 things): Blood flow to
area of absorption
First pass effect
Cellular membrane permeability (passive vs. active)
GI motility (absence/presence of food in stomach, other drugs)
18.Parenteral Absorption - affected by? (2 things): Blood flow to area of
absorp- tion
Cell membrane permeability (passive vs. active transport)
19.Bioavailability: Percentage of a drug that reaches the systemic
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