Basophils - ANS-Release histamines and immune reactions
HRO: Cytokines
Monocytes - ANS-Become tissue macrophages, which phagocytose and digest invading
microorganisms and foreign bodies as well as damaged and senescent cells
HRO: Cytokines
B Cells - ANS-Make antibodies
HRO: Cytokines
T cells - ANS-Kill virus-infected cells and regulate activities of other leukocytes
HRO: Cytokines
NK cells - ANS-Kill virus-infected cells and some tumor cells
Platelets - ANS-Initiate blood clotting. Cell fragments, arising from megakaryocytes in bone
marry
HRO: TPO (liver, kidney, skeletal muscles, and marrow)
Labs: 150,000- 400,000 uL
, IL-12 and IL-18 - ANS-Th 1
IFN activates macrophages to kill INTRAcellular bacteria
IL-4 - ANS-Th2
IL-4 activates macrophages to expel parasitic worms
IL-6, IL-21 - ANS-Tfh
Make IL-21, IL-4 and express CD40L and ICOS that help B cellls make high affinity class
switched antibody
Common variable immunodeficiency - ANS-Cause: Unknown, MCH linked
Defect: defective IgA and IgG production
Susceptibility: extracellular bacteria
Selective IgA - ANS-Most common!
Cause: Unknown; MCH linked
Defect: No IgA synthesis
Susceptibility: respiratory infections
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