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NUR 2060 Pharm Exam 1_ GI (1).
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NUR 2060 Pharm Exam 1_ GI (1).
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NUR 2060 Pharm Exam 1: GIPharmacologic classes of drugs that are anti ulcer agents - ANS-1. Antibiotics
2. Antisecretory agents : H2 Receptor Blockers and Proton Pump Inhibitors
3. Mucosal Protectants
4. Antisecretory agents that promote mucosal defenses
5. Antacids
Drugs that fit into the pharmacological class of antibiotics are used to eradicate H. pylori -
ANS-Sins and Souls! "cins and zouls"
1. amoxicillan (Amoxil)*
2. metronidazole (Flagyl)*
3. clarithromycin (Biaxin)
4. tetracycline (Achromycin V)
5. tinidazole (Tindamax)
In order to eradicate H. pylori what drug combination must be achieved? - ANS-2 antibiotics
combined with either an H2 Receptor Blocker OR a Proton Pump Inhibitor.
However, we should know:
amoxicillan (Amoxil) +metronidazole (Flagyl) +bismuth (Pepto)
Drugs that fit into the pharmacological class H2 Receptor Blockers that inhibit gastric acid
secretions. - ANS-"dine"
1. cimetidine (Tagamet)*
2. ranitidine (Zantac)*
3. nizatidine (Axid)
4. famotidine (Pepsid)
CAUTION:
Avoid antacids 1 hr before meds
bleeding abnormalities
some risk of pneumonia with decreased gastric acid in the GI causing bacterial colonization in
stomach and respiratory tract
DO:
increase head of bed (HOB)
inform of bleeding abnormalities
, In addition to the H2 Receptor Blocker CAUTIONS what should we be know about cimetedine
(Tagamet) in particular? - ANS-It causes confusion in the elderly
It inhibits cytP450 enzymes
What are H2 Receptory blockers used for with regard to antiulcer capacity? - ANS-Part of a
multi drug therapy to eradicate H. pylori
decrease symptoms and prevent complications of PUD
prevent NSAID induced ulcers
decrease heartburn
GERD
Zollinger-Ellison syndrome (hypersecretory)
Drugs that fit into the pharmacological class Proton Pump Inhibitors (PPI) and are used to
suppress gastric acid secretion by blocking the enzyme needed for acid formation. -
ANS-"prazole"
1. omeprazole (Prilosec)*
2. deslansoprazole (Dexilant)
3. esomeprazole (Nexium)
4. lansoprazole (Prevacid)
5. rageprazole (Acifphex)
6. pantoprazole (Protonix)
RISKS:
fractures, pneumonia, acid rebound, intestinal infection
C. diff leads to diarrhea
long term cancer risk
What are PPI's used for with regard to antiulcer capacity? - ANS-Preferred prophylactic to treat
PUD. In the event these cannot be used then use H2 Receptor Blockers.
GERD
prevent NSAID induced ulcers
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