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Samenvatting - Cel II celbio H7
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H7 samenvatting zowel lesnotities als info vanop slides.
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CEL 2: CELBIO H7Prof. Jolanda Van Hengel
, 1. Cellen integreren in weefsels
- Cel-cel/cel-ECM hech5ng
- Cel-cel en cel-ECM interac5es cruciaal voor:
o Assemblage van cellen tot weefsels
o Controle celvorm en fc5e
o Ontwikkelingsbestemming
à CAM directe cel-celadhesie
- Belangrijkste cel-cel en cel-matrix adhesie interac5es
o CAM
§ E-cadherine
§ CAM
§ Integrine
§ selec5ne
o Cel-matrixadhesie-adhesiereceptoren
à Integrale membraaneiwiFen-cytosolische domeinen
à Adapter-eiwiFen: verbinden CAM (in)direct met cytoskelet
2. EiwiFen vd ECM
- ECM-componenten:
o Proteoglycanen
o Collagenen
o Mul5-adhesieve matrix eiwiFen
§ Fibronec5ne
§ Laminine niet gelijk aan lamine!!
- Verschillende dichtheden (veel/weinig binweefsel)
- Func%es:
o Verankering en omringing
o Biomechanische eigenschappen
o Kenmerken (polariteit, overleving, prolifera5e, differen5a5e, bestemming)
o Celmigra5e remmen/vergemakkelijken
à spoor maken voor cellen om te tonen hoe ze moeten migreren
o Binden aan en fungeren als reservoir groeifactoren
o Ac5veren signaalreceptoren
- Fibronec5ne:
o Vereist voor takvorming
à Gebrekkige ontwikkeling van skeleFen à ECM is belangrijk!!
1. Signaalweg ac5veren –
binden met integrine
2. Clustering à FAK geac5veerd
3. Transfosforyla5e in FAK
4. P-Tyr verankerd in cytoplasma
à aantal neemt toe
5. Daaraan signaliserende EW
binden
à out to in signalisa5e
à Signalen naar rest van ECM (een
groot complex van allemaal EW
vormen à cte meer en meer
binden door fosforyla5e van
integrine)
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