Exam (elaborations)
HOI EXAM II MED CHEM TEST
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HOI EXAM II MED CHEM TEST ...
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HOI EXAM II MED CHEM TEST Mechlorethamine - ANSWER methyl group replaced with other substituents depending on the drug Dactinomycin - ANSWER phenazone ring bleomycin - ANSWER 2 thiazole rings Anthracyclines - ANSWER tetracycline + sugar intra-strand - ANSWER What type of linking does cisplatin make? Methotrexate - ANSWER - aliphatic are stronger electrophiles (given IV) and more toxic - aromatic are weaker electrophiles and useful (PO) in palliative care only - les s toxic, less effective - ANSWER Difference between aliphatic and aromatic N mustards acrolein binds to cysteine - ANSWER How does cyclophosphamide byprodu ct bind to the bladder? acrolein - ANSWER byproduct of cyclophosphamide Has a thiol that binds with acrolein and prevents it from binding to the bladder, so less toxicity when taking cyclophosphamide. - ANSWER Use of Mesna ototoxicity - take amifostine to avoid cochlear concentration - ANSWE R What toxicity can occur with cisplatin and what can you do to prevent it? nitrosoureas (cross BBB) - ANSWER Which can be used for CNS? prevent methylation of dUMP (thymines death) - ANSWER Goal of Fluorouracil Can't have OH in C2 position - ANSWER What cannot be present for fluorouraci l to be active?The benefits of buying summaries with Stuvia:
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