NURS 5334 - M1 exam with correct answers
Prescriptive ,,Authority ,,- ,,ANSWER: ,, ,,➡ ,,legal ,,route ,,to ,,prescribe ,,independently ,,and ,,without ,,limitation
Parts ,,of ,,a ,,prescription ,,- ,,ANSWER: ,, ,,➡ ,,- ,,prescriber ,,name ,,
- ,,license ,,number ,,
- ,,contact ,,information ,,
- ,,DEA ,,number ,,(prescriber ,,and ,,supervising) ,,
- ,,patient ,,name ,,
- ,,DOB ,,
- ,,allergies ,,
- ,,name ,,of ,,medication ,,
- ,,indication ,,
- ,,strength ,,
- ,,frequency ,,
- ,,signature
SIG ,,- ,,ANSWER: ,, ,,➡ ,,"let ,,it ,,be ,,labeled"; ,,instructions ,,for ,,the ,,prescription
Pharmacokinetics ,,- ,,ANSWER: ,, ,,➡ ,,the ,,study ,,of ,,the ,,drug ,,movement ,,throughout ,,the ,,body
Ways ,,for ,,drugs ,,to ,,cross ,,the ,,cell ,,membrane ,,- ,,ANSWER: ,, ,,➡ ,,1. ,,Channels ,,
2. ,,Pore ,,transport ,,systems ,,- ,,P-glycoprotein ,,system ,,
3. ,,Direct ,,penetration
Absorption ,,- ,,ANSWER: ,, ,,➡ ,,the ,,drug's ,,movement ,,from ,,the ,,site ,,of ,,administration ,,into ,,the ,,blood
, Factors ,,that ,,affect ,,absorption: ,,- ,,ANSWER: ,, ,,➡ ,,rate ,,of ,,dissolution, ,,surface ,,area, ,,blood ,,flow, ,,lipid
,,solubility, ,,pH ,,partitioning
pH ,,partitioning ,,or ,,ion ,,trapping ,,- ,,ANSWER: ,, ,,➡ ,,drug ,,molecules ,,tend ,,to ,,accumulate ,,on ,,the ,,side ,,of ,,the
,,membrane ,,where ,,pH ,,most ,,favors ,,ionization ,,- ,,i.e. ,,Acidic ,,drugs ,,accumulate ,,on ,,the ,,alkaline ,,side, ,,and
,,basic ,,drugs ,,accumulate ,,on ,,the ,,acidic ,,side
Distribution ,,- ,,ANSWER: ,, ,,➡ ,,the ,,drug's ,,movement ,,from ,,the ,,blood ,,into ,,the ,,interstitial ,,space ,,of ,,tissues
,,and ,,from ,,there ,,into ,,the ,,cells
Factors ,,that ,,affect ,,distribution: ,,- ,,ANSWER: ,, ,,➡ ,,circulation, ,,membrane ,,permeability, ,,protein ,,binding
Metabolism ,,(biotransformation) ,,- ,,ANSWER: ,, ,,➡ ,,enzymatically ,,mediated ,,alteration ,,of ,,drug ,,structure
Substrate ,,- ,,ANSWER: ,, ,,➡ ,,drugs ,,that ,,are ,,metabolized ,,by ,,the ,,P450 ,,hepatic ,,enzymes
Inducer ,,- ,,ANSWER: ,, ,,➡ ,,increase ,,the ,,rate ,,of ,,metabolism
Inhibitor ,,- ,,ANSWER: ,, ,,➡ ,,decrease ,,the ,,rate ,,of ,,metabolism
"First-pass ,,effect" ,,- ,,ANSWER: ,, ,,➡ ,,rapid ,,hepatic ,,inactivation ,,of ,,certain ,,oral ,,drugs
Excretion ,,- ,,ANSWER: ,, ,,➡ ,,drugs ,,and ,,their ,,metabolites ,,move ,,out ,,of ,,the ,,body
Elimination ,,- ,,ANSWER: ,, ,,➡ ,,the ,,combination ,,of ,,metabolism ,,of ,,excretion
Minimum ,,effective ,,concentration ,,- ,,ANSWER: ,, ,,➡ ,,amount ,,of ,,drug ,,required ,,to ,,produce ,,a ,,therapeutic
,,effect