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Androgens and Anti-Androgens Pharm Questions and Answers
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Androgens and Anti-Androgens Pharm Questions and Answers
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Androgens and Anti-Androgens PharmQuestions and Answers
What is the main androgen in humans? Where is it synthesized in males
and in females? -
correct answer ✅TESTOSTERONE is main androgen
Males: Leydyig cells
Females: Corpus luteum & Adrenal cortex
REVIEW: Testosterone in males is converted to DHT via what enzyme?
What is DHT needed for in males? -
correct answer ✅Testosterone is converted to DHT via 5-α-REDUCTASE
Testes require DHT for development
REVIEW: Testosterone is seen in both males and females, what enzyme
is seen in both genders that converts testosterone to estrogen? -
correct answer ✅AROMATASE
Converts testosterone to estrogen in both males and females
The effects of androgens are divided into ____ and _____ effects. There
(are or aren't) compounds that are specific for one effect? -
correct answer ✅ANDROGENIC and ANABOLIC effects
,Androgens and Anti-Androgens Pharm
Questions and Answers
There AREN'T any compounds specific for only one effect
List some of the Androgenic effects. -
correct answer ✅-Maturation of sex organs (penis, scrotum)
-Spermatogenesis
-Deepening of voice
-Growth of facial hair/axillary hair
-Libido
-Negative feedback on LH and FSH
List some of the Anabolic effects. -
correct answer ✅-Growth of muscle mass and strength
-Increased bone density and strength
T/F: No drugs are strictly anabolic or androgenic. -
correct answer ✅TRUE
In the absence of _____, the androgen receptors exists in the cytoplasm
associated w/ a ____-___ ____. How many forms of the androgen
receptors are there? -
correct answer ✅In the absence of LIGAND (an androgen), the
androgen receptors exists in the cytoplasm associated w/ a HEAT-SHOCK
PROTEIN.
, Androgens and Anti-Androgens Pharm
Questions and Answers
There are 2 isoforms of androgen receptors (1. AR-A 2. AR-B)
Testosterone enters its target cells by ____ ____ and is converted to ___
and _____ by the enzymes ______ and _____. -
correct answer ✅Testosterone enters its target cells by PASSIVE
DIFFUSION and is converted to DHT and ESTROGEN by the enzymes 5α-
REDUCTASE and AROMATASE
What happens to the androgen receptors once an androgen
(Testosterone/DHT) binds to it? -
correct answer ✅Receptor dissociates from the heat-shock protein --->
Dimerizes --> Translocates to the nucleus
Once the Androgen-Androgen Receptor complex translocates to the
nucleus what happens next? -
correct answer ✅-Complex binds to DNA and influences transcription
of androgen-sensitive genes
Besides androgens having an effect genomically (altering transcription),
what other effect can they have? What is the benefit of androgens that
do this? -
correct answer ✅NON-GENOMIC effects; act directly on ion
transporters and phosphorylation of key molecules in signal
transduction pathways
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