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Mobilization of Triglycerides

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This visual illustration displays the Usage of Triglycerides (fats and lipids) within the human body, step by step. It includes all reactants, products, enzymes, factors, and organs/systems involved.

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  • August 4, 2024
  • 1
  • 2023/2024
  • Class notes
  • Dr. maria azrad
  • All classes
All documents for this subject (6)
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carlieprescott
Mobilization of Triglycerides
lipolysis : breakdown of fats/lipids/triglycerides
* occurs in
fasting state *




Adipocyte
=




·
onis
O
,
3

CGI disassociates
is
perilipin-normally alpha cells in
pancreas release glucagon when
when perilipin
phosphorylated




cAMP

adenyly/ D
whenThes hormonbintproteinpedrecepti converts ATP to cAMp
cyclase AC
effector enzyme adenyly/ . . .




MGL
mono-glyceride
lipase
pineph (20 ) %




lycerol is soluble
calcohol
groups) so




J
it can enter blood
2, 3 .
PKA phosphorylates perilipin ,
which causes unassisted
-

C61 to dissociate from perilipin.
1
4
. 261 binds to and activates Adipose
Triglyceride Lipase (ATGL)
(TAG)
. ATGL
5 cuts an ester bond on the triglyceride ↑


to release I free fatty acid (FFA) ↑


and activates
phosphorylates

6 .
PKA then ↑


which
Hormone-Sensitive Lipase (HSL) ↑



6
,



diacylglycerol (DAG

From here , albumin can

o
releases 1 FFA from ↑
& ↑
FFAs to

transport
repeats with Mono-Glyceride V
&
- to be
. The same
7
3rd FFA
& other tissues
ATP
which
cuts oxidized to make
Lipase (MGL)
M
the
C
-




Stream
,



and glycerol from monoacyl glycerol (MAG) - -
-


end product : 3 FFAs + 1 glycerol


ATGL-TAG-FFAI
HSL-DAG-FFAZ

MGL- MAG-FFA2 +
glycerol

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