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Pharm 01 23 24 Questions with correct Answers 100% and detailed solutions
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Pharm 01 23 24 Questions with correct Answers 100% and detailed solutions
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STUVIAPharm 01/23/24
- ✔✔What is pharmacologic antagonism?`
% of administered dose that reaches the systemic circulation, related to the "first pass effect" -
✔✔What is the definition of bioavailability ?
`Production of a molecular / cellular response to an interaction between a molecule and a receptor
that activates the receptor. - ✔✔What is agonism?
A molecule that binds to the same receptor as an agonist but exerts the opposite pharmacological
response to that of a normal agonist.
Only occurs with receptors that have an active unbound state (constitute or basal activity). It is not
blocking activity of that receptor but it is slowing down its basal activity to have less action than
normal. - ✔✔What is an inverse agonist?
Absorption is the movement of drug molecules into the body, it can occur passively or via facilitated
diffusion. - ✔✔What is the absorption phase of the pharmacokinetic phse?
%
Altered capacity to metabolize and or excrete drugs. Usually both are decreased. - ✔✔How does
age affect dose and response of a drug?
Bind of a drug to a receptor that does not activate the receptor and prevents a response to an
agonist. - ✔✔What is antagonistic receptor binding?
Block can be overcome by increasing dose of the agonist - ✔✔What is a competitive antagonist?
Block can NOT be overcome by increasing dose of the agonist. AKA irreversible agent. - ✔✔What is
non-competitive antagonism?
Body systems, components, cellular level, and molecular level. - ✔✔What are the levels of drug
activity?
Buprenorphine works but is not as strong as methadone avoids respiratory depression. - ✔✔Why
would it be an advantage to give a partial agonist instead of full agonist?
Can affect all phases of pharmacokinetic and pharmacodynamic response. - ✔✔How do comorbid
medical conditions affect dose and response of drugs?
, STUVIA
Can be used for drugs that are poorly absorbed in the stomach (only about 10% of a dose of oral
vancomycin is absorbed).
Immediate onset of action like with opioid IV analgesics
Can provide longer lasting effect like with antipsychotics when they are given IM or SQ
Can concentrate a drug at a specific location like with corticosteroids being injected into a joint (IA)
Can provide a more predictable response like with antiobiotics in a septic patient.
Can provide titratable doses like with heparin infusions. - ✔✔What are some advantages of
parenteral administration of drugs?
Differences in body composition and hormonal activity. - ✔✔How does gender affect dose and
response of a drug?
Dilaudid is nearly seven times more potent. - ✔✔Why can we give less dilaudid than morphine to
produce the same analgesic effect?
Dissolved liquids, suspensions, powders, capsules, tablets, coated tablets / caplets, enteric coated
tablets, and sustained release. - ✔✔What the oral dosage forms that are available to us?
%
Drops that work locally, - ✔✔What kinds of drugs are given in the Ears?
Drops, or ointments, they have a local effect in the eye - ✔✔What kinds of drugs are given in the
eyes?
Enzymatic differences can lead to alterations in magnitude of effect. Can be either increased or
decreased and cause either toxicity or therapeutic failure respectively. - ✔✔How does genetics affect
dose and response of a drug?
GABA receptors exhibit basal activity
There are experimental compounds that can lower your basal GABA receptor effects and instead of
having normal level of relaxation, you become more anxious - ✔✔What is an example of a receptor
that can have an inverse and positive agonist activity?
Has a medium sized surface area, has a rich blood supply, and an acidic pH. Drugs dont stay in the
stomach for long - ✔✔How does the stomach work as a form of enteral administration?
High amount of surface area, rich blood supply, basic pH - ✔✔How does the small intestine work as
a form of enteral administration?
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