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2024 NR 565 PHARMACOLOGY WEEK 4 EXAM WITH CORRECT ANSWERS
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2024 NR 565 PHARMACOLOGY WEEK 4 EXAM WITH CORRECT ANSWERS
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2024 NR 565 PHARMACOLOGYWEEK 4 EXAM WITH CORRECT
ANSWERS
Allopurinol hypersensitivity syndrome - CORRECT ANSWERS-Severe, can be
life threatening
Rash, fever, liver dysfunction, renal dysfunction
Stop allopurinol, seek medical attention
Don't take antihistamines
Adverse reactions: Colchicine - CORRECT ANSWERS-Rhabdomyolysis
Increased risk in patients who take statins
Discuss potential risk of muscle injury
Mechanism of action: Urate-lowering drugs/xanthine oxidase inhibitors -
CORRECT ANSWERS-Treat underlying cause of gout flare-ups
Initial Febuxostat therapy - CORRECT ANSWERS-Decrease production of uric
acid = prevent gout attacks
In the beginning, symptoms may flare
Colchicine or NSAIDs are given for up to 6 months to prevent flares
Uricosuric agents - CORRECT ANSWERS-Probenecid
Benzbromarone
Sulfinpyrazone
Lesinurad
Probenecid - CORRECT ANSWERS-Used for chronic gout
Can exacerbate acute episodes
Delay treatment until acute attack subsides
Allopurinol and Warfarin - CORRECT ANSWERS-Allopurinol may delay
metabolism of warfarin
Warfarin dose should be decreased when allopurinol is added
Osteoporosis - CORRECT ANSWERS-Decreased bone mineral density and
bone mass
Changes in quality or structure of bones
Increased risk of osteoporotic fractures
, Osteoporosis treatment goals - CORRECT ANSWERS-Slow or stop bone loss
Prevent fractures
Osteoporosis: Postmenopausal women - CORRECT ANSWERS-Inadequate
intake of dietary calcium
Requires supplementation
Osteoporosis: CPGs - CORRECT ANSWERS-Men and PM women > 50 should
be considered for treatment if:
Hip or vertebral fracture
T-score of -2.5 or less @ femoral neck or spine
Low bone mass
Medication therapy: Osteoporosis - CORRECT ANSWERS-Bisphosphonates
Denosumab (RANKL inhibitor)
Raloxifene
Medications for osteoporosis: Bisphosphonates - CORRECT ANSWERS-
Alendronate
Ibandronate
Zoledronic acid
Bisphosphonate treatment rank - CORRECT ANSWERS-1st line for PM women
with prior hip or vertebral fracture
DXA T-score of -2.5 or less
Mechanism of action: Bisphosphonates - CORRECT ANSWERS-Inhibits
osteoclast activity = decreased bone resorption
Mediations for osteoporosis: Denosumab (RANKL Inhibitor) - CORRECT
ANSWERS-Prolia
Xgeva
Denosumab (RANKL Inhibitor) treatment rank - CORRECT ANSWERS-
Alternative initial treatment for PM women with osteoporosis and increased
risk of fractures
Most common inflammatory form of arthritis - CORRECT ANSWERS-Gout
Characteristics: RA - CORRECT ANSWERS-Rapid onset
3:1 in women/men
Age 35-50 years at onset
Affects hands and feet
local and systemic inflammation
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