CRO 2024 Final Exam 2 Study Guide Questions & Answers
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Course
CRO 2024
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CRO 2024
CRO 2024 Final Exam 2 Study Guide Questions & Answers
Where is the common site of metastasis after chemo-RT (2-year incidence) for patients with small cell lung cancer? - ANSWERSBrain metastasis (50-80% incidence) is a common site of relapse after chemo-RT
What are the most important progno...
CRO 2024 Final Exam 2 Study Guide
Questions & Answers
Where is the common site of metastasis after chemo-RT (2-year incidence) for patients with small cell
lung cancer? - ANSWERSBrain metastasis (50-80% incidence) is a common site of relapse after chemo-RT
What are the most important prognostic factors for a patient with small cell lung cancer? -
ANSWERSstage, performance status
What is the preferred fractionation and total dose administered for BID treatment of small cell lung
cancer? - ANSWERS45 Gy bid fractionation (1.5 Gy bid)
What is the spinal cord limit for a patient receiving BID treatment for small cell lung cancer? -
ANSWERS<36 Gy with bid RT
What is the dose limit for the brachial plexus for a patient receiving radiation for small cell lung cancer? -
ANSWERSlimit maximum dose to <66 Gy
What are the dose limits for the esophagus and heart for a patient receiving radiation for small cell lung
cancer? - ANSWERS• max dose < 105% of prescription; mean < 34 Gy
What are the acute and late complications for a patient receiving radiation for small cell lung cancer? -
ANSWERS• Acute- esophagitis, dermatitis, cough, fatigue
• Late - radiation pneumonitis, rib fracture, esophageal stricture or perforation, coronary artery disease
What percent of SCLC cases are associated with a history of tobacco exposure? - ANSWERSMore than
95%
What is the #1 cause of cancer death in the US and worldwide? - ANSWERSNon-small cell lung cancer
, Greater than 90% of cases of non-small cell lung cancer are associated with - ANSWERSSmoking or
involuntary smoking
What subtype of non-small cell lung cancer is NOT associated with smoking (and what is it associated
with)? - ANSWERSAdenocarcinoma in situ (AIS) (formerly known as bronchioalveolar carcinoma) is a
subtype of adenocarcinoma that is weakly associated with smoking. It is associated with prior lung
disease.
When following radiation for non-small cell lung cancer when does radiation pneumonitis occur and
what are the presenting symptoms? How is it treated? - ANSWERSRadiation pneumonitis occurs about 6
weeks after RT. It presents with cough, dyspnea, hypoxia, and fever. Treat radiation pneumonitis with
prednisone.
What is the most common cause of NSCLC in US? - ANSWERSRadon is the second most common.
Smoking is the most common.
Large cell carcinoma tends to be located. It has a high propensity to metastasize to -
ANSWERSPeripherally, brain
Tends to be centrally located with lower propensity for brain metastasis - ANSWERSSquamous cell
What are the prognostic factors for NSCLC? - ANSWERSstage, weight loss, KPS, pleural effusion
What are the dose limits for the spinal cord, esophagus (max dose), heart, and total lung for a patient
receiving radiation for non-small cell lung cancer? - ANSWERSCord: RT alone: max dose less than 50Gy
Chemo-RT: max dose less than 46Gy at 1.8-2Gy/fx QD or less than 36Gy with
bid RT; Lung: Total lung V20 less than 40%, Chemo-RT V20 less than 35% Max dose for esophagus less
than 75Gy o Heart: V40Gy less than 80%
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