✓~ intact skin and mucous membranes (impermeable barrier)
PAMP
,✓~ pathogen associated molecular pattern
surfaces of bacteria, viruses, and other microbes are covered with many foreign
proteins
foreign
DAMP
✓~ damage associated molecular pattern
many proteins are released from inside our cells when they are damaged
foreign
PRR
✓~ pattern recognition receptors
surfaces of WBCs contain these receptor sites
,-continuously interact with any material they encounter to ID it as "self" or
"non-self" (foreign; PAMP or DAMP)
Chemotaxis
✓~ Cell movement that occurs in response to chemical stimulus
Phagocytosis
✓~ "cell eating"
1. opsonization and adherence
2. engulfment - WBC surrounds and ingests Ag
3. Fusion of phagosome with lysosome
4. destruction - phagosome digested by lysozyme, H202, acids, and other toxic
chemicals inside the lysosomes
5. egestion
Hypersensitivity Type 1:_____
✓~ Allergic reaction
, Hypersensitivity: Type 1
Mediated by ______
✓~ IgE
Hypersensitivity: Type 1
Inflammation due to _____________
✓~ mast cell degranulation
Hypersensitivity: Type 1
local symptoms
✓~ itching, rash
Hypersensitivity: Type 1
systemic symptoms
✓~ wheezing
Hypersensitivity: Type 1
most dangerous form
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