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NSG-318 Topic 7 Part 1 Questions and Correct Answers
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Inflammation ◦Protective response to tissue injury and infection ◦A vascular reaction occurs causing fluid, blood elements, leukocytes, and chemical mediators (prostaglandins) to accumulate at the injured site Vascular phase What inflammatory phase occurs 10 to 15 minutes after injury and is c...

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  • August 8, 2024
  • 6
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • nsg 318 topic 7 part 1 questions and correct answe
  • inflammation protective response to tissue injur
  • vascular phase what inflammatory phase occurs 10

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NSG-318 Topic 7 Part 1 Questions and
Correct Answers
Inflammation ✅◦Protective response to tissue injury and infection
◦A vascular reaction occurs causing fluid, blood elements, leukocytes, and chemical
mediators (prostaglandins) to accumulate at the injured site

Vascular phase ✅What inflammatory phase occurs 10 to 15 minutes after injury and is
characterized by:
◦Vasodilation and increased capillary permeability
◦Fluid and blood substances move to injured site

Delayed phase ✅What inflammatory phase is characterized by leukocytes infiltrating
inflamed tissue

COX ✅Cyclooxygenase enzyme

Converts arachidonic acid into prostaglandins ✅What does COX enzyme do?

COX-1 ✅What enzyme protects stomach lining and regulates blood platelets

COX-2 ✅What enzyme triggers inflammation and pain?

Cardinal signs of inflammation ✅◦Redness
◦Swelling
◦Heat
◦Pain
◦Loss of function

Antiinflammatory drug groups ✅-Nonsteroidal antiinflammatory drugs (nsaids)
-Corticosteroids
-Disease-modifying antirheumatic drugs
-Antigout drugs

Action of nsaids ✅-Inhibit biosynthesis of prostaglandins
-Analgesic effect
-Antipyretic effect
-Inhibit platelet aggregation
-Mimic effects of corticosteroids
-Inhibit COX enzymes

First generation nsaids ✅-Salicylates

, -Parachlorobenzoic acid derivatives
-Phenylacetic acids
-Propionic acid derivatives
-Fenamates
-Oxicams

Second generation nsaids ✅-Selective COX-2 inhibitor

First generation nsaids ✅Inhibit COX-1 and COX-2

Second generation nsaids ✅only inhibit COX-2

Salicylates ✅Aspirin (acetylsalicylic acid) (ASA)

Aspirin action ✅◦Anti-inflammatory, antiplatelet, antipyretic effects

15 to 30 mg/dl ✅therapeutic serum salicylate level

Greater than 30 mg/dl ✅What is the mild toxic serum salicylate level?

Greater than 50 mg/dl ✅What is the severe toxic serum salicylate level?

Salicylate drug interactions ✅◦Increased bleeding with anticoagulants and other nsaids
◦Risk for hypoglycemia with oral antidiabetics
◦Increased gastric ulcer risk with glucocorticoids
◦Decreased effects of ACE inhibitors, loop diuretics, probenecid
◦Salicylate effects are decreased by corticosteroids

Salicylate lab interactions ✅◦Increase PT, bleeding time, INR, uric acid
◦Decrease cholesterol, T3 and T4 levels

Foods containing salicylates ✅◦Prunes, raisins, licorice
◦Certain spices such as curry and paprika

Aspirin cautions ✅◦Do not take with other nsaids
◦Avoid during the last trimester of pregnancy
◦Do not give to children with flu or virus symptoms as it may lead to Reye syndrome

Aspirin Side effects/adverse reactions ✅◦CNS effects
◦Tinnitus, hearing loss
◦GI distress, bleeding, blood disorders
◦Hepatotoxicity, Reye syndrome
◦Hypersensitivity: Tinnitus, dizziness, bronchospasm

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