ANS B) Institute twice-weekly complete blood count with differentials and monitor closely.
The recommended cut-points for discontinuation of clozapine are WBC of 2,000 to 3,000 or
granulocytes of 1,000 to 1,500 for agranulocytosis and severely com- promised immune
system. At a WBC of 4,000, the recommendation is to closely monitor CBC with differential
twice a week while patient may continue clozapine inthe absence of any other signs or
symptoms.
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