Which disease state is caused by loss of approximately 80% of the RAG proteins enzymatic activity and
misssense mutation? (hint: infant has a red rash on the face and shoulders) - Omenn Syndrome
Major histocompatibility complex class I presents: - Intracellular antigens to CD8 T cells
__________...
PCB 3233 IMMUNOLOGY - EXAM 3
Which disease state is caused by loss of approximately 80% of the RAG proteins enzymatic activity and
misssense mutation? (hint: infant has a red rash on the face and shoulders) - Omenn Syndrome
Major histocompatibility complex class I presents: - Intracellular antigens to CD8 T cells
__________ has an alpha chain and a beta chain in their structure while ________ only has an alpha
chain in its structure? - MHC II, MHC I
What process(es) are used after activation to make MHC I and II binding sites better? - None of
the above (Somatic recombination, somatic hypermutation, isotype switching
Burkitt's lymphoma is due to a translocation of the ________ gene next of one of the ________ genes. -
MYC, Ig
You would expect the IgA and IgB genes to be turned on (expressed) during which stage/s? - All
the above (the small pre B cell, mature B cell, immature B cell
T-cell receptor diversity is established - Before antigen stimulation
The types of human MHC I presenting molecules are: - HLA-A, HLA-B and HLA-C which present
peptide to CD8 T-cells
Receptor editing - A & B (is done on the light chain, can be utilized in an attempt to rescue a B-cell
that has a self-reactive receptor
Which one of the following is in the correct sequence? - Early Pro-B, Late Pro-B, Large Pre-B, Small
Pre-B, Immature B-cell
, When/where are N and P nucleotide additions added to the variable regions (binding site? -
During somatic recombination
Which chemokine/s call/s a B-cell into the follicle of a secondary lymphoid tissue? - CXCL 13
Which cell/s is/are lymphocyte/s? - None of the above (neutrophils, macrophages, dendritic cells
Which of the following is/are considered proto-oncogenes? - A & B (BCL2, MYC)
A mature B-cell has: - IgM, IgD and IgA and IgB on the surface
Which cell types can become a plasma cell? - All the above (a memory B-cell, an activated B-cell, a
centrocyte
The types of human MHC II presenting molecules are: - HLA-DP, HLA-DQ, HLA-DR which present
peptide to CD4 T-cells
True of false: CCL19 and CCL21 direct a B-cell out of the blood stream, across HEV's and into a secondary
lymphocyte toward the T-cell era. - True
The peptide-binding groove of an MHC class I molecule is composed of the following extracelllular
dendritic cells? - a1 : a2
A beta (B) chain of a TCR has: - 1 variable region and 1 constant region
The genetic diversity of the MHC molecules binding site is due to: - Genetic polymorphism
Follicular dendritic cells: - A & B (are present in germinal centers, are present in secondary
lymphoid
True or false: A T-cell uses somatic hypermutation to make its binding site better. - False
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