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PARATHYROID PHARMACOLOGY QUESTIONS AND ANSWERS STUDY GUIDE WITH COMPLETE SOLUTION!!
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PARATHYROID PHARMACOLOGY QUESTIONS AND ANSWERS STUDY GUIDE WITH COMPLETE SOLUTION!!
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PARATHYROID PHARMACOLOGY QUESTIONS AND ANSWERSSTUDY GUIDE WITH COMPLETE SOLUTION!!
Where is PTH made and secreted?
Answers :Chief Cells in parathyroid gland
what stimulates PTH synthesis and secretion?
Answers :low plasma Ca2+
and high plasma phosphorus
Where does PTH bind?
Answers :Plasma membrane PTH receptors (GPCRs) in kidney and bone
What does PTH do in the kidney?
Answers :Increase reabsorption of Ca2+
decrease reabsorption of phosphate
stimulate 1-hydroxylation of vitamin D to form active 1,25-dihydroxyvitamin D
Net effect of PTH on kidney
Answers :Increase plasma Ca2, decrease plasma phosphate
Effect of PTH in bone
, Answers :Acts directly on osteoblast and osteoclast precurosrs to stimulate
cytokines that increase production and activiy of osteoclasts ( M-CSF and RANK
ligand)
leads to increased bone remodeling
Continuous PTH stimulation
Answers :favors bone resorption= increase plasma ca2+
Pulsatile PTH
Answers :favors bone formation
maybe increase osteoblast number via increased production and decreased
osteoblast apoptosis
two forms of vitamin D
Answers :Vitamin D2 (ergocalciferol)
Vitamin D3 (Cholecalciferol)
biologicaly equivalent
undergo 2 step hydroxylation to form active 1,25-dihydroxyvitamin D, first in liver
(25-hydroxylation), then in kidney (1-hydroxylation)
where is vitamin D2 obtained?
Answers :diet
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