Lehne's Pharmacology CH 28 questions with correct answers
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Lehne\'s Pharmacology
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Lehne\'s Pharmacology
are drugs that relieve pain without causing the loss of consciousness
analgesics
are the most effective pain relievers available
any drug, natural or synthetic, that has actions similar to morphine
opioids
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Lehne's Pharmacology CH 28 questions with
correct answers
are drugs that relieve pain without causing the loss of consciousness - ANSWER: ➡
m m m m m m m m m m m m mm
analgesics
m
are the most effective pain relievers available
m m m m m m
any drug, natural or synthetic, that has actions similar to morphine - ANSWER: ➡ opioids
m m m m m m m m m m m m mm m
compounds present in opium - ANSWER: ➡ opiate
m m m m m mm m
Three families of peptides - ANSWER: ➡ Enkephalins
m m m m m mm m
Endorphins
Dynorphins
Analgesia, respiratory depression, euphoria, sedation, and physical dependence - ANSWER:
m m m m m m m m m m
➡ Mu receptors
m m m
Analgesia and sedation m m
may underlie psychotomimetic effects seen with certain opioids - ANSWER: ➡ Kappa
m m m m m m m m m m mm m
receptors
m
Strong opioid agonists and moderate to strong opioid agonists - ANSWER: ➡ Morphine
m m m m m m m m m m mm m
Moderate to strong agonists - ANSWER: ➡ codeine
m m m m m mm m
,Agonist-Antagonist Opioids - ANSWER: ➡ Pentazocine m m m mm m
Nalbuphine
Butorphanol
buprenorphine
IMPORTANT: Do not give these meds to a person who is taking Agonist Opioids regularly for
m m m m m m m m m m m m m m m
chronic pain
m m
Prototype of the pure opioid antagonists - ANSWER: ➡ Naloxone [Narcan]
m m m m m m m mm m m
Peripherally acting mu opioid antagonist developed
m m m m m
Counteracts the adverse effects of opioids on bowel function
m m m m m m m m
Does not reduce opioid-mediated analgesia: Limited ability to cross the blood-brain barrier
m m m m m m m m m m m
Short-term therapy of opioid-induced ileus after partial small or large bowel resection with
m m m m m m m m m m m m
primary anastomosis - ANSWER: ➡ Alvimopan
m m m m mm m
What is the main source of morphine? - ANSWER: ➡ seedpod of the poppy plant
m m m m m m m m mm m m m m m
Pharmacological actions of Morphine - ANSWER: ➡ Pain relief
m m m m m mm m m
Drowsiness
Mental clouding m
Anxiety reduction m
Sense of well-being
m m
Respiratory depression m
, Constipation
Urinary retention m
Orthostatic hypotension m
Emesis
Miosis
Cough suppression m
Biliary colic m
Tolerance and physical dependence m m m
Therapeutic Uses of Morphine - ANSWER: ➡ Relieves pain without affecting other senses
m m m m m mm m m m m m m
(for example, sight, touch, smell, and hearing)
m m m m m m m
No loss of consciousness
m m m
Relieve pain by mimicking the actions of endogenous opioid peptides, primarily at mu
m m m m m m m m m m m m
receptors
m
Adverse Effects of Morphne: Respiratory Depression - ANSWER: ➡ Infants and the elderly
m m m m m m m mm m m m m
are especially sensitive
m m m
Onset varies by route
m m m
Tolerance to this effect can develop m m m m m
Increased depression with concurrent use of other drugs that have CNS depressant actions
m m m m m m m m m m m m
(for example, alcohol, barbiturates, and benzodiazepines)
m m m m m m m
Can compromise patients with impaired pulmonary function
m m m m m m m
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