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gms 6552: cell signaling and therapeutics review exam 1 Questions With Complete Solutions
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gms 6552: cell signaling and therapeutics review exam 1 Questions With Complete Solutions
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gms 6552: cell signaling and therapeutics review exam 1Questions With Complete Solutions
which type of receptor most often utilizes second messenger
systems in its signaling?
GPCRs
assume you have receptor antagonists that are able to stop
receptor signaling immediately. for which type of receptor
would take the longest to see the effects of your drug at the
cellular level?
nuclear receptors
which type of receptor would having adequate membrane
permeability of an agonist be most critical?
nuclear receptors
is it more like for a GPCR agonist to bind near the N- or C-
terminus of the receptor?
N terminus
is it more likely to find a GPCR bound to a G-protein that is also
bound to GTP or GDP?
GDP
which protein ultimately is translocated from the cytoplasm to
the nucleus as a result of JAK signaling?
, STAT
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where, in relation to the protein-coding region of a gene, are the
binding sites that become occupied by nuclear receptors?
upstream
the levels of which second messenger would be expected to
increase following administration of nitroglycerin?
cGMP
does TGF-beta treatment cause cells to grow more of less in the
soft agar assay?
more
the latent TGF-beta peptide must be cleaved by what protease in
order to be activated?
plasmin
in the TGF-beta pathway, which protein becomes activated first
upon binding of a ligand?
TGFBR2
how many DNA binding domains do SMADs have?
1
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