STUVIA 2024/2025
Chapter 28: Peptides, Antimalarials, and
Anthelmintics
A patient who has traveled to an area with prevalent malaria has chills, fever, and diaphoresis. The
nurse recognizes this as which phase of malarial infection?
a. An erythrocytic phase
b. An incubation phase
c. A prodromal phase
d. A tissue phase - ✔✔✔ANS: A
The erythrocytic phase of malarial infection occurs when the parasite invades the red blood cells and
is characterized by chills, fever, and sweating.
A patient is preparing to travel to a country with prevalent malaria. To prevent contracting the disease,
the provider has ordered chloroquine HCl (Aralen). The nurse will instruct the patient to take this drug
according to which schedule?
a. 500 mg weekly beginning 2 weeks prior to travel and continuing for 8 weeks after travel
b. 1000 mg weekly beginning 2 weeks prior to travel and continuing for 8 weeks after travel
c. 500 mg once followed by 500 mg per dose in 6 hours, 24 hours, and 48 hours
%
d. 1000 mg once daily for 2 days followed by 500 mg daily for 2 to 3 weeks - ✔✔✔ANS: A
For malaria prophylaxis, chloroquine is started 2 weeks before entering an endemic area and then
continued for 8 weeks after leaving the area. The dose is 500 mg weekly. The dosing schedule of
1000 mg once daily for 2 days followed by 500 mg daily for 2 to 3 weeks is used to treat acute
malaria.
A patient is taking chloroquine (Aralen) to treat acute malaria. Which statement by the patient
indicates understanding of this medication?
a. "I should abstain from alcohol while taking this medication."
b. "I will have to take this medication indefinitely to avoid recurrence of my infection."
c. "I should report visual changes immediately."
d. "I should take this drug on an empty stomach." - ✔✔✔ANS: C
Patients taking chloroquine (Aralen) should report any visual changes or symptoms to the provider.
One does not need to abstain from alcohol, but if the patient drinks large amounts of alcohol or has a
liver disorder, the liver enzymes will require closer monitoring. The patient will likely need to be on
therapy for 2-3 weeks, not indefinitely.
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